MESOCORTICAL ANATOMY AND PLASTICITY

此应用程序概述了一个持续（年7-9）的研究计划， 阐明皮层（中皮层）的神经解剖学组织 形成了所谓的边缘叶。 的 中皮质形成了大部分的皮质内侧表面上的 大脑半球，以及众所周知的区域，如扣带回， 海马旁回、眶额后区和颞极区 是主要元素。 长期目标是了解他们的 与大脑皮层的关系 概述了三个持续的目标：（1） 第一个也是主要的目的是进行实验性神经解剖学研究， 中皮层的连接使用顺行和逆行 （2）第二个目标是以光学显微镜为中心 在深层颞叶结构，如杏仁核， (3)第三个目标是研究评估轴突 使用荧光素的中皮质连接的侧支化 双标记技术。 连接研究解决的内在和 中皮质的连合投射，神经再支配研究集中在 杏仁外侧核和双标记研究评估轴突 后海马旁、扣带回和 眶额区 这项研究有基础也有临床 神经科学相关性 中皮层是连接的， 在建筑结构上处于中间地位， 将联合皮层与边缘系统相互连接。 当这个 在神经系统疾病衰弱性疾病中， 与记忆力、注意力和情绪有关。 神经再支配 研究集中在经常涉及头部创伤的颞叶区域， 与创伤后行为变化有关， 临床设置。 为节省成本， 以连锁的方式设计，并部分借鉴了 过去15年来在哈佛收集的非人类灵长类动物材料 医学院（1969-1978年）和爱荷华州大学（1979-1984年）。 没有一 拟议的调查完全依赖于所有新的一代 研究材料。

This application outlines a continuing (years 7-9) research plan designed to elucidate the neuroanatomical organization of the corices (mesocortices) that form the so-called limbic lobe in the old-world monkey. The mesocortices form a large part of the cortex on the medial surface of the cerebral hemisphere, and well-know areas like the cingulate gyrus, parahippocampal gyrus, posterior orbitofrontal area and temporal polar area are major elements. The major long term goal is to understand their relationship with the neocortex. Three continuing aims are outlined: (1) the first, and major aim entails experimental neuroanatomical studies on the connections of the mesocortices using anterograde and retrograde tracing techniques, (2) the second aim centers around light microscopic reinnervation studies in deep temporal lobe structures like the amygdala, (3) the third aim is represented by studied that assess axon collateralization in mesocortica connections using fluorexcent double-labeling techniques. Connection studies address the intrinsic and commissural projection of the mesocortices, reinnervation studies focus on the lateral amygdaloid nucleus and double-labeling studies assess axon collateralization in the posterior parahippocampal, cingulate and orbito-frontal areas. The research has basic as well as clinical neuroscience relevance. The mesocortices are connectionally and architecturally intermediate in structure, sharing the features of interconnecting the association cortices with the limbic system. When this relationship is disrupted in neurological disease debilitating disorders relating to memory, attention and emotion results. The reinnervation studies focus on temporal lobe areas involved frequently in head trauma and hold relevance to post-traumatic changes in behavior seen frequently in the clinical setting. To conserve costs the individual investigations are designed in an interlocking fashion and draw in part on a collection of non-human primate material gathered over the past 15 years at Harvard Medical School (1969-1978) and the University of Iowa (1979-1984). None of the proposed investigations rely exclusively on the generation of all new research material.