MESOCORTICAL ANATOMY AND PLASTICITY

概述了一项具有双重目的的持续计划 研究起源于边缘的皮质神经系统 非人灵长类的肺叶及其病理改变 它们可能是阿尔茨海默病中的同源物。这个 边缘或中皮质构成了内侧表面的主要部分。 灵长类动物的大脑，包括扣带回等区域 皮质、海马旁皮质、后眶额叶皮质和 颞极的大脑皮层。校长的中心目标是 调查人员的研究努力一直是为了阐明 中皮质与等皮质缔合的关系 形成海马体结构的区域和分配皮质。 这是AIMS的一个有利可图的补充，这是在过去的几年里发展起来的 5年来，一直在铸造阿尔茨海默氏症的病理模式 从实验结果看疾病 神经解剖学研究。非人灵长类动物实验研究， 它们仍然是赠款的核心，建立了 中皮质神经元和病理学研究服务于建立 它们在一种自然发生的人类疾病中可能的破坏 以中脑皮质为目标。大脑皮层的五个区域将 接受进一步调查。这些包括时间极点， 内嗅区、周围区、枕颞区和后扣带区 皮质。在猴子身上的实验研究的目标将集中在 投射到大脑皮层的中皮质轴突的起源 与地形、层流有关的联合区 投射神经元的组织和分离 离散和非离散种群。与以下事项有关的调查 阿尔茨海默氏症将检查细胞结构同源物 人类大脑中的这些区域，重点是地形图 以及使用这两个标准的病理学的层状组织 病理染色和单抗ALZ-50。有动力 根据先前的研究进展，假设中皮质神经元 将大脑皮层的关联区与 阿尔茨海默病的病理靶点是海马体结构 疾病。神经系统疾病中这种关系的中断 会导致记忆、情绪和注意力的衰弱障碍。 个人调查具有成本效益，并在一定程度上吸引了人们 在收集的大量实验材料上 哈佛医学院过去19年的首席研究员 学校(1969-1978年)和爱荷华大学(1979-至今)。 此外，70多例患者的完整颞叶传导阻滞 阿尔茨海默氏症在首席调查员的 过去7年的实验室是可用的。

A continuing plan is outlined that has the dual purpose of investigating cortical neural systems that arise from the limbic lobe in the nonhuman primate and the pathological alteration of their probable homologues as seen in Alzheimer's disease. The limbic, or mesocortices, form a major part of the medial surface of the primate brain and include such areas as the cingulate cortex, parahippocampal cortex, posterior orbitofrontal cortex and the cortex of the temporal pole. The central goal of the principal investigator's research effort has been to elucidate the relationship of the mesocortices with the isocortical association areas and the allocortices that form the hippocampal formation. A profitable addition to the aims, that has evolved over the past 5 years, has been to cast the patterns of pathology in Alzheimer's disease in the perspective of results from experimental neuroanatomical studies. Nonhuman primate experimental studies, which remain the core of the grant, establish the connectivity of mesocortical neurons, and pathological studies serve to establish their probable disruption in a naturally occurring human illness that targets the mesocortex. Five areas of the mesocortex will receive further investigation. These include the temporal polar, entorhinal, perirhinal, occipitotemporal and posterior cingulate cortices. The aims of experimental studies in monkeys will focus on the origin of mesocortical axons that project to cortical association areas with regard to their topography, laminar organization and the segregation of projection neurons into discrete and nondiscrete populations. Investigations relating to Alzheimer's disease will examine the cytoarchitectural homologues of these areas in the human brain, with a focus on the topography and laminar organization of pathology using both standard pathological stains and the monoclonal antibody Alz-50. Motivated by previous progress, it is hypothesized that mesocortical neurons that interconnect the cortical association areas with the hippocampal formation are targeted for pathology in Alzheimer's disease. Disruption of this relationship in neurological disease yields debilitating disorders of memory, emotion and attention. The individual investigations are cost effective and draw in part on a large collection of experimental material gathered by the principal investigator over the past 19 years ar Harvard Medical School (1969-1978) and the University of Iowa (1979-present). Additionally, complete temporal lobe blocks from over 70 cases of Alzheimer's disease processed in the principal investigator's laboratory over the past 7 years are available.