CELLULAR NEURONAL CONTROL OF BEHAVIOR

本项目的目标是研究核弹头的重复发射特性。 在行为产生中扮演特定角色的神经元。三种类型 要检查的重复发射特性包括：适应性， 回弹激发，并产生猝发。我们将研究这些机制 心中有四个问题： 1)每个过程的离子机制是什么？ 2)细胞之间重复激发特性的差异是由于 质的差异，即特定渠道类型的存在？ 或者，是数量差异，例如通道密度或 渠道动力学，更重要？当通道动力学在两个之间变化时 细胞类型，是否存在影响几种不同类型的一般差异 频道类型？ 3)突触是如何调节重复放电特性的 发射机？ 4)特定细胞的重复放电特性是如何 对塑造由该细胞控制的行为有何贡献？ 我们将使用全细胞电压钳和膜片钳技术来研究 这些问题存在于海兔腹神经节的识别神经元中。 对决定不同的离子机制的完整描述 神经元重复放电特性的各个方面是必不可少的 以全面了解正常生理学和 神经系统的病理生理学。

The goal of this project is to study the repetitive firing properties of neurons with defined roles in the generation of behavior. The three types of repetitive firing characteristics to be examined are: adaptation, rebound excitation, and burst generation. We will examine these mechanisms with four questions in mind: 1) What is the ionic mechanism for each process? 2) Are differences in repetitive firing properties between cells due to qualitative differences, i.e., presence of a particular channel type? Alternatively, are quantitative differences, such as channel density or channel kinetics, more important? When channel kinetics vary between two cell types, is there a general variation affecting several different channel types? 3) How are repetitive firing characteristics modulated by synaptic transmitters? 4) How do the repetitive firing characteristics of a particular cell contribute to shaping the behavior controlled by that cell? We will use whole cell voltage clamp and patch clamp techniques to study these problems in identified neurons in the abdominal ganglion of Aplysia. A complete description of the ionic mechanisms that determine different aspects of the repetitive firing characteristics of neurons is essential for a complete understanding of the normal physiology and the pathophysiology of the nervous system.