PREFRONTAL CORTEX AND TEMPORAL INFORMATION PROCESSING

在目前的拨款建议中，主要目的将是测试 就前额叶而言，动物和人类之间存在着对应关系 大脑皮质对记忆功能的调节。有人提出，基本的 前额叶皮质受损的人的缺陷是无法排序 在短期时间基础上的信息。这是基于临床上的 关于预期功能的认知测验的观察和缺陷 处理提前计划和回顾功能的能力 对相对新近的记忆处理进行了测量。 最近，在大鼠身上建立了一种行为模型，在这种模型中，一个人可以 测量(A)用于迷宫上地点列表的订购信息的存储器， (B)用于以下各项之间基于时间的关联关系列表的存储器 特定刺激(食物提示和迷宫上的位置)，以及(C)对一组的记忆 在特定刺激(食物暗示)之间进行基于时间的比较。 我建议使用这个动物模型作为一种手段来研究 前额叶皮质在调节信息的时间顺序中的作用。第一 目的是确定大鼠内侧前额叶皮质 调解在各种测试中测量的信息的时间顺序 认知功能。 第二个目标是确定函数的可能唯一性 内侧前额叶皮质在眼眶岛叶中的作用 前额叶皮质和丘脑内侧-背侧向内侧的投射 和眼眶-岛叶前额叶皮质。 希望从这些研究中收集的信息将提供一个 对额叶综合征的理解 治疗干预是可以建立的。

In the present grant proposal, the major purpose will be to test whether there is a correspondence between animals and humans in terms of prefrontal cortex mediation of memory function. It has been proposed that the basic deficit in humans with prefrontal cortex damage is the inability to order information on a short-term temporal basis. This is based on both clinical observations and deficits on cognitive tests in which prospective functions dealing with the ability to plan ahead as well as retrospective functions dealing with memory for relative recency are measured. Recently, a behavioral model has been developed in rats in which one can measure (a) memory for order information for a list of places on a maze, (b) memory for a list of temporally based associative relationships between specific stimuli (food cues and places on a maze), and (c) memory for a set of temporally based comparisons between specific stimuli (food cues). I propose to use this animal model as a means of investigating the role of prefrontal cortex in mediating temporal ordering of information. The first aim is to determine whether the medial prefrontal cortex in the rat mediates temporal ordering of information as measured in a variety of tests of cognitive function. The second aim is to determine possible uniqueness of function of the medial prefrontal cortex by examining the role of the orbital-insular prefrontal cortex and the medial-dorsal thalamic projections to the medial and orbital-insular prefrontal cortex. It is hoped that the information gleaned from these studies will provide an understanding of the frontal lobe syndrome such that a rationale therapeutic intervention can be established.