NARCOLEPSY--CLINICAL RESEARCH TO IMPROVE TREATMENT

发作性睡病是一种原因不明的神经系统疾病， 每1000名美国人中就有1人。临床上，嗜睡症最早出现在青春期 或年轻的成年期作为无法抗拒的睡眠冲动。辅助症状是 猝倒、催眠幻觉和睡眠瘫痪。这种疾病已经 与一系列问题有关，从“在校成绩不佳”到 “婚姻不幸福”到“死于交通事故”。 这项研究旨在评估最常用的治疗方法 来治疗这种疾病。我们将完成一种双盲，多药， 发作性睡病患者药物治疗的多剂量水平研究。一个 采用重复测量设计，并设正常对照组。 正在研究以评估重复测量的效果并收集 规范性数据。 我们计划完成比较四种药物的相对有效性的研究。 控制发作性睡病嗜睡的常用药物： 帕莫林、哌替林甲酯和右旋苯丙胺。

Narcolepsy is a neurological disorder of unknown origin that afflicts about 1 in 1000 Americans. Clinically, narcolepsy first appears in adolescence or young adulthood as irresistible urges to sleep. Auxillary symptoms are cataplexy, hypnagogic hallucinations and sleep paralysis. The disease has been linked to problems ranging from "under achievement in school" to "unhappy marriage" to "death in traffic accidents." The research is designed to evaluate the most frequently used treatments for this disorder. We will complete a double-blind, multiple-drug, multiple-dose level study on drug therapy in narcoleptic patients. A repeated-measures design has been employed and a normal control group is being studied to assess the effect of repeated measurement and to gather normative data. We plan to complete studies comparing the relative effectiveness of four drugs in common use for control of excessive somnolence in narcolepsy: pemoline, methylphenidate protriptyline, and dextroamphetamine.