ELECTROCORTICOGRAPHIC CHANGES WITH HUMAN HIGHER FUNCTION

皮层脑电(ECoG)伴随人体高级功能的变化 涉及语言的大脑皮质直接记录在清醒、行为 患者在手术过程中发生的独特机会 癫痫的治疗。寻求从解剖学上讲的ECOG变化 特定于那些被独立识别为必需的皮质部位 这是通过电刺激映射来发挥作用的，在那里，行为 具体来说，即在使用相同感觉输入的任务中缺席，但 具有不同的更高功能。这项建议是延期。 我们以前的工作中，变化是在视觉上确定的平均 对无声命名具有解剖和行为特异性的ECOG：Slow 额叶语言部位的诱发电位与脑电的去同步化 后置语言站点。去同步化的衡量标准是 静脉曲张个体化试验中皮层脑电的谱密度技术 命名，并在统计学上证实了其特异性。独一无二的EP 形态与短期言语的解剖学和行为学特异性 记忆已经被识别、测量，而且这种特异性得到了证实 从统计学上讲。静语时皮层脑电变化的初步观察 与以下更改相比，阅读内容有所不同 无声命名。现在的POSS通过以下方式扩展这些研究：测量 判断EP是否与运动语言功能相关 记忆也发生在额部，用解剖学证实了ECoG的变化 和行为特异性来阅读和识别ECoG事件 这种对听觉命名、单词重复和语音的专一性 身份证明。在这些情况下发生的人口变异性 将确定事件(迄今在患者个人中确定)。 这些ECoG事件的范围和行为关联的细节 将检验语言皮质是由马赛克组成的假设 相当大的行为特定性。在不同的时间举行活动的时间 同一患者体内的部位将决定串联或并联的程度 对特定功能的处理。这些事件的形态可以 暗示了潜在的神经生物机制。这些研究将会增加 我们对人类大脑中语言功能发生的位置的理解，以及 神经生物机制在这些行为过程中起作用。

Electrocorticographic (ECoG) changes accompanying human higher functions involving language are recorded directly from cortex in awake, behaving patients during the unique opportunity that occurs with the surgical treatment of epilepsy. ECoG changes are sought that are anatomically specific to those cortical sites independently identified as essential to that function by electrical stimulation mapping, and there, behaviorally specific, that is, absent on tasks using the same sensory input but processed with different higher functions. This proposal is an extension of our previous work where changes were visually identified in the averaged ECoG that had anatomic and behavioral specificity to silent naming: slow evoked potentials (EP's) at frontal language sites and desynchronization at posterior language sites. That desynchronization has been measured with spectral density techniques on ECoG during individual trials of silent naming, and the specificity confirmed statistically. An EP of unique morphology with anatomic and behavioral specificity to short-term verbal memory has been identified, measured, and that specificity confirmed statistically. Preliminary observations of ECoG changes during silent word reading have been made with some differences compared to changes with silent naming. The present posposal extends these studies by: Measurement of EP's related to motor speech function, determining if the EP related to memory also occurs at frontal sites, confirming ECoG changes with anatomic and behavioral specificity to reading, and identifying ECoG events with such specificity to auditory naming, word repetition and speech sound identification. The population variability in the occurrence of these events (identified to date in individuals patients) will be determined. The details of the extent and behavioral correlation of these ECoG events will test the hypothesis that language cortex is organized in mosaics of considerable behavioral specificity. The timing of events at different sites in the same patient will determine the degree of serial or parallel processing of a particular function. The morphology of these events may suggest underlying neurobiologic mechanisms. These studies will increase our understanding of where in the human brain language functions occur, and the neurobiologic mechanisms operative there during those behaviors.