THERAPY OF CENTRAL NERVOUS SYSTEM ISCHEMIA

中风是这个国家第三大最常见的死亡原因，也是 中枢神经系统(CNS)缺血是最常见的中风类型。 目前尚无公认的治疗缺血性心脏病的特效药。 中风。在之前的支持期间，我们开发了一种方法 生化、组织学和药理学的详细探索 用兔脊髓缺血模型研究局灶性中枢神经系统缺血的方向性。 通过这项技术，我们发现几种5-羟色胺的抑制剂可以 减少因缺血造成的神经损伤。 在拟议的研究中，我们将调查三个方面：1)研究 5-羟色胺抑制剂如何减少中枢神经系统缺血损伤；2)测定 包括去甲肾上腺素抑制剂在内的其他几种药物， 钙通道阻滞剂和前列腺素抑制剂也可以减少中枢神经系统 损伤；3)探讨动脉血压的变化如何影响 中枢神经系统缺血。为了进行这些研究，我们将使用兔脊髓 脑缺血模型测试这些实验操作是否影响中枢神经系统 缺血性损伤。我们还将测量地球上许多地方的生物胺 并测定脊髓局部血流量，建立 这些药物的作用。我们的研究将表明这些 治疗策略对患者有潜在的好处。 缺血性卒中，并将有助于我们了解其作用机制 这样我们就可以为中枢神经系统设计更有效的治疗方法 缺血症。

Stroke is the third most frequent cause of death in this country, and focal central nervous system (CNS) ischemia is the most common type of stroke. At present there are no generally accepted specific treatments for ischemic strokes. During the previous period of support we developed a method for detailed exploration of biochemical, histological and pharmacological aspects of focal CNS ischemia using a rabbit spinal cord ischemia model. With this technique we found that several inhibitors of serotonin can reduce the amount of neurological damage produced by ischemia. In the proposed studies we will investigate three areas: 1) examination of how serotonin inhibitors reduce CNS ischemic damage; 2) determination of whether several other types of drugs including norepinephrine inhibitors, calcium channel blockers and prostaglandin inhibitors can also reduce CNS injury; 3) exploration of how alterations of arterial blood pressure affect CNS ischemia. To perform these studies we will use the rabbit spinal cord ischemia model to test whether these experimental manipulations affect CNS ischemic damage. We will also measure biogenic amines in many parts of the spinal cord and determine regional spinal cord blood flow to establish the actions of these drugs. Our studies will indicate whether these therapeutic strategies are of potential benefit for patients who suffer ischemic strokes, and will help us understand the mechanisms of action of these treatments so we can design even more effective therapies for CNS ischemia.