The potential of membranes – peptide engineering to modulate ion channels

该项目旨在开发一种平台技术，以识别基于能够与膜相互作用和跨膜的超稳定毒肽的新型和选择性钠通道抑制剂。钠通道几乎涉及到人体生理的各个方面。选择性地抑制单个钠通道亚型并了解是什么驱使多肽具有跨膜能力的能力将是一项重大成就，并将带来新的神经科学研究工具和技术。该项目提议的技术可以转化为与生物技术产业相关的新知识。

This project aims to develop a platform technology to identify new and selective sodium channel inhibitors based on ultra-stable venom peptides that can interact with and cross membranes. Sodium channels are involved in almost all aspects of human physiology. The ability to selectively inhibit individual sodium channel subtypes and to understand what drives peptides' ability to cross membranes would be a major achievement and lead to new neuroscience research tools and technologies. This project’s proposed technology could be translated into new knowledge relevant to the biotechnology industry.