NEUROPSYCHOLOGICAL ASPECTS OF STAGE II/III HIV INFECTION

人类免疫缺陷病毒的嗜神经特性 (HIV)艾滋病病毒能够引起 人的原发性神经和心理异常 获得性免疫缺陷综合征（AIDS）。 有 然而，关于患病率、临床 表现、自然病程和潜在的公共卫生影响 在不太严重的艾滋病病毒中， 感染 我们将通过进行个案控制来解决这些问题 在三组同性恋者中进行的前瞻性队列研究 活跃男性：80例持续性全身淋巴结病 (CDC第三组艾滋病毒感染），其中许多人已在 我们详细介绍了长达四年的时间; 80名无症状艾滋病毒感染者- 血清阳性男性（CDC第二组）和80名艾滋病毒血清阴性男性。 每名受试者将接受一系列详细的神经系统检查， 标准化神经心理学（心理测量）测试，文化 外周血淋巴细胞检测HIV，并监测T 淋巴细胞亚群 神经心理学测试将包括 智力、注意力、集中力、长时间和 短期记忆，认知灵活性，信息处理， 运动速度、视觉辨别力和其他特性。 60名HIV感染者（II组和III组各30名） 第三组艾滋病毒感染）将每年进行腰椎穿刺， 脑脊液HIV培养和HIV测定 在皮内产生HIV抗体。 40名受试者的子集 第二阶段和40名第三阶段艾滋病毒感染者（所有这些人都将 接受CSF检查）将进行连续磁共振检查 脑部扫描 神经心理学的自然史 艾滋病毒感染的表现将由纵向 随访长达五年。

The neurotropic properties of human immunodeficiency virus (HIV) are well established, as is the ability of HIV to cause primary neurological and psychological abnormalities in persons with overt acquired immunodeficiency syndrome (AIDS). There is little information, however, on the prevalence, clinical manifestations, natural course, and potential public health impact of neuropsychological aberrations in less severe forms of HIV infection. We will address these issues by conducting case control and prospective cohort studies in three groups of homosexually active men: 80 with persistent generalized lymphadenopathy (CDC group III HIV infection), many of whom have been studied in detail by us for up to four years; 80 asymptomatic HIV- seropositive men (CDC group II); and 80 HIV-seronegative men. Each subject will undergo serial detailed neurologic examinations, standardized neuropsychological (psychometric) testing, culture of peripheral blood lymphocytes for HIV, and monitoring of T lymphocyte subsets. The neuropsychological tests will include measurements of intelligence, attention, concentration, long- and short-term memory, cognitive flexibility, information processing, motor speed, visual discrimination, and other characteristics. Sixty of the HIV-infected subjects (30 each with group II and group III HIV infection) will undergo annual lumbar punctures with cerebrospinal fluid culture for HIV and determination of intrathical production of antibody to HIV. A subset of 40 subjects with stage II and 40 with stage III HIV infection (all of whom will undergo the CSF studies) will have serial magnetic resonance brain scans. The natural history of the neuropsychological manifestations of HIV infection will be determined by longitudinal followup for up to five years.