PAPILLOMAVIRUS AND ORAL CANCER--A CASE-CONTROL STUDY

人乳头瘤病毒（HPV）在口腔粘膜中流行， 参与口腔鳞状细胞癌的病因学。 没有研究， Date已经评估HPV是口腔癌的危险因素。 拟议 这项研究是对65名在纽约大学登记的患者进行的病例对照研究。 德克萨斯医学博士安德森癌症中心与以前未经治疗， 组织学证实的口腔鳞状细胞癌和74名年龄，性别， 和种族匹配的对照组。 病例和对照已累计， 病史问卷数据已经收集并自动化。 收集关于HPV流行率的实验室数据， 诱变剂诱导的染色体断裂最近完成。 的 HPV抗体应答的测量将使用 HPV衍生的合成肽作为酶联免疫吸附试验中的抗原 免疫测定法 血清学应答数据和HPV感染率及分型 数据将作为口腔癌的风险因素进行评估， 分析. 来自自填风险因素问卷的数据， 诱变剂诱导的染色体敏感性数据将与 HPV数据。 拟议研究的结果将为以下方面提供依据： 评估HPV感染作为可能标志物的更大规模前瞻性研究 for tumor肿瘤development发展.

Human papillomavirus (HPV) is prevalent in the oral mucosa and may be involved in the etiology of oral squamous cell carcinoma. No study to date has evaluated HPV as a risk factor for oral cancer. The proposed research is a case-control of 65 patients registered at the University of Texas M.D. Anderson Cancer Center with previously untreated, histologically confirmed oral squamous cell carcinoma and 74 age-, sex- and race-matched controls. The cases and controls have been accrued, and medical history questionnaire data have been collected and automated. Collection of laboratory data concerning the prevalence of HPV and mutagen-induced chromosome breakage was recently completed. The measurement of the antibody response to HPV will be accomplished using HPV-derived synthetic peptides as antigens in an enzyme-linked immunoassay. The serologic response data and HPV prevalence and typing data will be evaluated as risk factors for oral cancer in univariate analysis. Data from self-administered risk factor questionnaires and mutagen-induced chromosome sensitivity data will be integrated with the HPV data. The results of the proposed study will provide a basis for larger prospective studies to evaluate HPV infection as a possible marker for tumor development.