METHADONE TREATMENT: BEHAVIORAL/PHARMACOLOGICAL VARIABLE

美沙酮治疗的参数可以被系统地操纵 从而确定它们对治疗结果的贡献。这 提案将检查各种这样的行为和药理学 美沙酮维持和美沙酮范围内的参数 解毒。这个项目的目的有三个方面。第一，要 评估可用于以下方面的应急管理程序 美沙酮维持治疗患者的临床管理。第二，因为 许多阿片类药物滥用者不愿参与长期的美沙酮 维护计划，我们建议检查各种参数 非卧床美沙酮脱毒，以确定非卧床美沙酮 戒毒可能是一种可行而有效的治疗选择。 最后，本研究得到的技术和知识库 将在地方、地区、国家和 国际基础上，以进一步打击艾滋病毒的战斗。药物 滥用和艾滋病毒感染的传播。 待评估的具体应急管理程序包括 用带回家的特权加强无毒小便，加强 参加技能培训课程，带回家的特权，以及 用带回家的特权加强会议治疗计划目标。 美沙酮非卧床脱毒的剂量和时间参数 将在不愿参与美沙酮的客户中进行检查 维持治疗。添加应急措施的其他好处 在门诊戒毒期间的管理计划也将是 已评估。 这些研究将提供有关亲属的重要信息。 美沙酮应急管理程序的有效性 处理设置，以及一般实用和最佳参数 非卧床美沙酮戒毒。包括在研究设计中的 是多个结果衡量标准，以确定相对疗效 不同维度(如吸毒行为、就业状况、 成瘾严重程度中的精神状态和全球指数 索引)。延长的后续行动也将包括在设计中 戒毒方案，以确保全面的信息 受试者治疗后的功能。这些数据将为 对治疗的暂时性和持久性益处进行评估。

The parameters of methadone treatment may be systematically manipulated so as to determine their contributions to treatment outcome. This proposal will examine a variety of such behavioral and pharmacological parameters within the context of both methadone maintenance and methadone detoxification. The purpose of this project is three-fold. First, to evaluate contingency management procedures that could be utilized in the clinical management of methadone maintenance patients. Second, because many opiate abusers are unwilling to participate in a long-term methadone maintenance program, we propose to examine various parameters of ambulatory methadone detoxification, in order to determine if ambulatory detoxification can be a viable and efficacious treatment alternative. Finally, the technologies and knowledge-base resulting from this research will be rapidly disseminated on a local, regional, national, and international basis in order to further the battle against i.v. drug abuse and the spread of HIV infection. The specific contingency management procedures to be evaluated included reinforcing drug free urines with take-home privileges, reinforcing attending skills training classes with take-home privileges, and reinforcing meeting treatment plan objectives with take-home privileges. The dose and duration parameters of ambulatory methadone detoxification will be examined in clients who do not wish to participate in methadone maintenance treatment. The additional benefits of adding a contingency management program during ambulatory detoxification will, also, be evaluated. These studies will provide important information about the relative efficacy of contingency management procedures within the methadone treatment setting, and of the general utility and optimal parameters for ambulatory methadone detoxification. Included in the study designs will be multiple outcome measures so as to determine relative efficacy along different dimensions (e.g. drug use behaviors, employment status, psychiatric status, and global indices found in the Addiction Severity Index). An extended follow-up will also be included in the design of the detoxification protocols to ensure comprehensive information on subjects'post-treatment functioning. These data will provide for the evaluation of both the transient and the enduring benefits of treatment.