EXERCISE, AGING, AND SULFOCONJUGATED CATECHOLAMINES

这项研究考察了衰老对血浆游离和 静息和运动应激时的硫代偶联儿茶酚胺。 此外，这些措施中的运动训练的影响将 要下定决心。硫代偶联反应是一种重要的失活反应 游离儿茶酚胺(CA)的释放机制 交感神经系统和肾上腺。低硫凝固度 游离CA的增加与高血压有关。前进 时序年龄的特征是血浆游离CA增加 休息和体力消耗时的浓度，原因是 出现率提高，清晰度降低。到目前为止没有 研究检查了老年人CA清除量的减少 个体的部分原因是相对于游离硫结合作用较低 胺的出镜率。为了解决这个问题，20名健康的男性 年龄30-40岁和20名55-65岁的健康男性将接受检查 休息时和15分钟内。次极量运动(70%最大摄氧量)。 年龄组将进一步归类为高适合度(45-55岁) 毫升·公斤-1分钟-1)和中等适中(25-35毫升·公斤-1分钟-1)。无血浆 和磺基结合的CA图谱将被检查以确定任何年龄 影响和任何年龄×心血管健康交互作用。 此外，10名实验男性(年龄55-65岁)将接受 12周的运动训练计划，并与对照组进行比较 确定发生在游离酸及其磺基偶联物上的适应 游离态与硫键结合态CA的比值。这项研究已经 重要性体现在1)确定是否减少 硫代偶联是CA清除的一种机制 与提前的时间年龄妥协，2)识别 假设的低硫结合能力是否与高级 通过保持较高的心血管水平来延缓衰老 健身，以及3)检查是否设计了干预计划 增加心血管健康，并导致慢性 酚磺酸转移酶活性高的组织增强灌流 通过增加磺基结合来刺激减少的游离血浆CA， 因此反映了活跃的和更期望的比率 非活动表单。这项研究提供了对 随着年龄的增加，神经内分泌过程，以及 提供对心血管潜在重要性的洞察 保持神经内分泌的健身和运动训练 功能正常。

This research examines the impact of aging on plasma free and sulfconjugated catecholsmines at rest and during exercise stress. Furthermore, the impact of exercise training in those measures will be determined. Sulfoconjugation is an important deactivation mechanism for free catecholamines (CA) released from the sympathetic nervous system and adrenal gland. Low sulfoconjuration of free CA has been linked to essential hypertension. Advancing chronological age is characterized by augmented plasma free CA concentrations at rest and during physical exertion, due to heightened appearance rate and reduced clearanced. To date no study has examined whether the reduced clearance of CA in older individuals is due in part to low sulfoconjugation relative to free amine appearance rates. To address this issue, 20 healthy males aged 30-40 yrs and 20 healthy males aged 55-65 yrs will be examined at rest and during 15 min. of submaximal exercise (70% V02 max). The age groups will be further categorized into high-fit (45-55 ml.kg-1 min-1) and moderate-fit (25-35 ml.kg-1 min-1). Plasma free and sulfoconjugated CA profiles will be examined determine any age effect and any age x cardiovascular fitness interaction. Additionally, 10 experimental males (aged 55-65 yrs) will undergo a 12 wk exercise training program and be compared to controls to identify adaptations occurring with free CA, their sulfoconjugates, and the ratio of free to sulfocnonjugated CA. This research has importance in terms of 1) determining whether reduced sulfoconjugation is one mechanism by which clearance of CA is compromised with advancing chronological age, 2) identifying whether the postulated low sulfoconjugation ability with advanced age is attenuated by maintaining a high level of cardiovascular fitness, and 3) examining whether an intervention program designed to increase cardiovascular fitness and resulting in chronically enhanced perfusion of tissue high in phenosulfotransferase activity stimulates reduced free plasma CA with increased sulfoconjugation, thus reflecting a more desireable ratio between the active and inactive forms. This research provides further understanding of neuroendocrine processes with advancing chronological age, and offers insight into the potential importance of cardiovascular fitness and exercise training for maintaining neuroendocrine functioning.