Core Capability - University of York

约克大学化学系是约克大学最大的研究型部门之一，拥有约50名学术人员，57名研究员，136名博士（30名由EPSRC资助，12名由NERC资助）和14名硕士/硕士研究生。我们的化学分析对研究文章的发表至关重要，这些分析是在许多领先的研究中心进行的，例如，约克质谱卓越中心（CoEMS），约克磁共振中心（YCMR），约克JEOL纳米中心和磁共振超极化中心（CHyM）。本次招标是为了购买新的/替换设备，以支持我们在以下活动中的领先研究：核磁共振光谱：我们寻求400 MHz固态核磁共振系统的资金，作为我们研究活动的重要延伸，鉴于固体/软物质在许多研究和技术领域的巨大重要性，如多相催化，绿色化学，材料和纳米科学。此外，我们将为固态核磁共振方法学研究做出贡献，这将使我们的超极化研究包括表面物质/催化的核磁共振研究，也将扩展非常规的计算研究（基于自旋动力学），这些研究将扩展到比目前可能的更复杂、更依赖时间的现象。质谱：与布鲁克道尔顿合作，约克卓越质谱中心（CoEMS）提供了独特的组合和广泛的仪器，其中核心部分是我们的FT-ICR仪器，该仪器已升级为新的solariX。FT-ICR是质谱法中提供最高分辨率和精度测量的方法。我们目前的仪器规格（9.4T solariX）在m/z 400的分辨率为1.5 x 10 / 6。凭借其MALDI和ESI源，它也能够成像ms。我们现在寻求将solariX升级到更高的分辨率和精度，以捕获越来越复杂的天然混合物（如化石和生物燃料）的全方位信息，以及许多其他当前的分析挑战，如大气气溶胶的分子水平表征和探测完整的蛋白质和蛋白质组件。小角度x射线衍射：“软物质”包括一系列不同的材料，从膜脂、洗涤剂、聚合物、纳米颗粒到液晶；即日常生活中不可或缺的系统。这些系统的性质和应用需要对结构和局部分子组织有详细的了解。以前，结构是从偏振光显微镜推断出来的，然而，随着功能材料相的复杂性增加，现代x射线衍射已经成为结构表征的标准。该请求旨在通过购买带有定制样品支架的衍射仪来扩展我们对自组装系统的前沿研究，以研究散装，薄膜和设备中的相结构。荧光x射线光谱学：2009年，UoY优先购买微型x射线荧光（Horiba XGT-7000 Micro XRF）。该仪器提供非破坏性的元素分析，超过CHN （ppm水平），直接从样品（固体或液体），不消化使用有害强酸（即，强制性的火焰原子吸收）。该设备目前无法使用，需要更换和维修部件。

The Chemistry Department in York is one of University's largest research-led departments, with approximately 50 academic staff, 57-research fellows, 136 PhD (30 funded by EPSRC, 12 by NERC), and 14 MSc/MRes research students. Our chemical analyses are critical for the publication of research articles and these are made at a number of leading research centres for example, the York Centre of Excellence in Mass Spectrometry (CoEMS), York Centre for Magnetic Resonance (YCMR), York JEOL Nanocentre, and the Centre for Hyperpolarisation in Magnetic Resonance (CHyM). This bid is made for new/replacement equipment to support our leading research in the following activities: NMR Spectroscopy: We seek funding for a 400 MHz solid state NMR system as a vital extension to our research activities, given the huge importance of solid/soft matter in numerous research and technological areas such as heterogeneous catalysis, green chemistry, materials and nano-science. In addition, we will contribute to solid state NMR methodology research, which will allow our hyperpolarization research to include NMR studies of surface species/catalysis, and also to the expansion of unconventional computational research (based on spin dynamics) that will be extended to much more complicated, time-dependent phenomena than is currently possible.Mass Spectrometry: In collaboration with Bruker Daltonics, the Centre of Excellence in Mass Spectrometry (CoEMS) in York was supplied with a unique combination and breadth of instrumentation, the centre piece of which is our FT-ICR instrument, which was upgraded to the new solariX. FT-ICR is the method that provides the highest resolution and accuracy measurements in mass spectrometry. The specification of our current instrument (9.4T solariX) has a resolution of 1.5 x 10 sixth at m/z 400. With its MALDI and ESI sources, it is also capable of imaging MS. We now seek to upgrade the solariX to the even higher resolving power and accuracy required to capture the full range of information for increasingly complex natural mixtures like fossil- and bio-fuels and many other current analytical challenges such as the molecular-level characterization of atmospheric aerosols and probing intact proteins and protein assemblies.Small Angle X-Ray Diffraction: "Soft-matter" comprises a family of differing materials from membrane lipids, detergents, polymers, and nanoparticles to liquid crystals; ie, systems integral to every-day-life. The properties and applications of such systems require detailed understanding of structure and local molecular organisation. Previously, structures were inferred from polarized light microscopy, however, as the complexities of the phases of functional materials increase modern X-ray diffraction has become the standard for structural characterisation. This request is directed at extending our cutting edge research on self-assembling systems, via the acquisition of a diffractometer with custom-made sample holders, to study phase structures in the bulk, in thin films, and in devices. Fluorescence X-ray Spectroscopy: In 2009, UoY prioritised the purchase of a micro-X-ray fluorescence (Horiba XGT-7000 Micro XRF). The instrument provides non-destructive elemental analysis, beyond CHN (ppm levels), directly from the sample (solid or liquid) without digestion using hazardous strong acids (ie, mandatory for flame atomic absorption). The equipment is currently unusable and needs parts replacing and repair.