LASER-INDUCED NOVEL POTENTIAL ANTICANCER INDOLES

脱氧核糖核酸(DNA)被认为是一种 临床上有用的抗肿瘤药物的数量。建议的目标是 正在研究开发新的、更有效的DNA活性药物 用于光动力激光诱导的人类癌症的化疗或 病毒病原体灭活或两者兼而有之。此外，这项研究还描述了 将有助于现有的对影响的了解，并 激光诱导损伤的激光-物质相互作用机理 物质，特别是细胞和亚细胞水平的物质，人们知之甚少。 在这个时候，也是许多研究小组紧张研究的主题。 本研究的目的是获取和分析 吸收光谱、荧光光谱和电泳法 DNA和/或某些新型介离子吲哚衍生物的密度学示踪 在纳秒激光照射之前和之后。吸收量 荧光数据将使用Scatchard方程进行分析。 照相产品将用高效液相色谱法进行分析，并用CHN元素进行表征 通过IR、UV、~(13)C、~(13)C、~(13)

Deoxyribonucleic acid (DNA) is believed to be the molecular target of a number of clinically useful antitumor agents. The goal of the proposed research is the development of new and more effective DNA reactive drugs for the photodynamic laser-light induced chemotherapy of human cancers or inactivation of viral pathogens or both. Additionally, the study described in this proposal will contribute to existing knowledge of the effects and mechanisms of laser-matter interaction because laser-induced damage to matter especially at cellular and sub-cellular level is poorly understood at this time and is the subject of intense study of many research groups. The aim of the present study is the acquisition and analysis of the absorption spectra, fluorescence spectra and the electrophoretic densitometric traces of DNA and/or some novel mesoionic indole derivatives prior to and subsequent to nanosecond Nd:YAG laser irradiation. Absorption and fluorescence data will be analyzed using Scatchard equation. Photoproducts will be analyzed by HPLC and characterized by CHN elemental analysis and spectroscopically by IR, UV, 'HNMR, 13C NMR and MS.