SECOND INT1 WORKSHOP-ORAL MANIFESTION OF HIV INFECTION

这项提案要求提供资金，以允许出席和积极 青年科学家的参与，主要来自发展中 各国在第二届国际口语研讨会上 艾滋病毒感染的表现将于1月31日在旧金山举行- 1993年2月3日。因为对年轻人的资金极度有限 来自发展中国家的科学家参加这种水平的会议， 该请求强调对外国参与者的支持。大致 预计将有350名科学家参加研讨会。其中，大约有一个 第三个将来自美国以外的国家，特别是欧洲、加拿大和 中南美洲。艾滋病毒研究的各个方面，因为它与 口腔将被覆盖，范围从基础分子病毒学和 真菌学，通过临床和流行病学研究，以精神- 社会、行为和法律问题。 口腔内的病变是艾滋病最早的特征之一。 它们的不同性质和普遍存在体现在广泛的 和不断增长的文学作品。患有口腔念珠菌病的非艾滋病患者 在疫情早期就显示出高风险类别具有预测性 爱滋病患者。随着毛状白斑的发现，很快就变得清晰起来 这也是艾滋病毒感染和随后的 艾滋病的发展。除了它们在艾滋病毒诊断中的作用之外 感染，并作为艾滋病毒疾病进展的指标，口腔 病变被用作临床上与CD4计数相关的指标，作为 进入临床试验，以及易于研究和可获得的模型 针对HIV感染中的粘膜免疫异常。这些损伤会导致 严重的发病率，但许多可以用相当简单的方法治疗 治疗方法。 对这类病变的研究范围从流行病学和自然界 历史研究，通过基础分子病毒学、真菌学和粘膜学 免疫学，社会和行为研究。在第一届国际博览会上 研讨会，1988年在圣地亚哥举行，这一领域的少数先驱 与大约150人分享了他们的工作，其中许多人已经离开 做出自己的重大贡献。现在时机已经成熟， 5年后，为第二次研讨会，在此期间，大量 最近的和新的工作可以整合在一起，并与另一组 该领域潜在的新调查人员，特别是来自部件的调查人员 在世界上艾滋病流行注定增长最快的地方 戏剧性的。预计接受支持的人将 拟议的会议拨款将把他们自己的计划带回 在研讨会上获得的知识，他们将在那里应用这些知识，从而 为这些国家的艾滋病研究、护理和教育作出贡献 最迫切需要这种改善的地方，以及北方 美国。

This proposal requests funding to permit attendance and active participation of young scientists, predominately from developing countries, at the Second International Workshop on the Oral Manifestations of HIV Infection to be held in San Francisco January 31- February 3, 1993. Because of the extreme limitation on funds for young scientists from developing countries to attend meetings of this caliber, the request emphasizes support for foreign participants. Approximately 350 scientists are expected to attend the workshop. Of these, about a third will be from outside the U.S.A., notably from Europe, Canada and Central/South America. All aspects of HIV research as it relates to the mouth will be covered, ranging from basic molecular virology and mycology, through clinical and epidemiological research to psycho- social, behavioral and legal issues. Lesions in the mouth were among the first documented features of AIDS. Their varied nature and common occurrence is reflected in an extensive and growing literature. Oral candidiasis in non-AIDS patients who were in high-risk categories was shown early in the epidemic to be predictive of AIDS. With the discovery of hairy leukoplakia, it soon became clear that this was also an indicator of HIV infection and the subsequent development of AIDS. In addition to their role in the diagnosis of HIV infection and as indicators of the progression of HIV disease, oral lesions are used as clinical correlates of CD4 counts, as criteria for entry into clinical trials and as readily studied and accessible models for mucosal immune abnormalities in HIV infection. These lesions cause significant morbidity, yet many can be treated using fairly simple therapeutic approaches. Research on this group of lesions ranges from epidemiology and natural history studies, through basic molecular virology, mycology and mucosal immunology, to social and behavioral studies. At the 1st International Workshop, held in San Diego in 1988, a handful of pioneers in this field shared their work with approximately 150 people, many of whom have gone on to make their own significant contributions. The time is now ripe, 5 years later, for a second workshop, during which the large amount of recent and new work can be integrated and shared with a further group of potential new investigators in the field, particularly those from parts of the world where the AIDS epidemic is destined to grow most dramatically. It is anticipated that recipients of support from the proposed conference grant will take back to their own programs the knowledge acquired at the Workshop where they will apply it, thus contributing to AIDS research, care and education in those countries where such improvements are most sorely needed, as well as in North America.