STATE-DEPENDENT EFFECTS OF DRUGS ON COGNITIVE FUNCTIONING

本研究计划有五个具体的长期目标：（1） 目的是建立一种新的动物模型，用于研究 药物对认知功能的影响 Maier的三表推理机将 作为一种独特的工具来测试老鼠的能力， 将在一种化学状态下获得的信息与 在另一种化学状态下学习解决空间定位问题 食物奖励 研究表明，解决问题的过程 这个问题与大多数学习任务中涉及的问题不同 这取决于连续事件的关联（Maier，1932 a; 斯塔尔和埃伦，1974年）。 第二个目标是确定毒品的类别 这一现象的发生。 非处方药和 将研究受管制物质。 据推测，国家- 对咖啡因和尼古丁等药物的依赖性表现， 以及滥用受管制药物，如吗啡和美沙酮。 (3)第三个目标是确定在一个 一种药物（如吗啡）可以被另一种药物（如纳洛酮）阻断 或者药物和阻滞剂的组合， 第三化学态 (4)第四个目标是启动几个试点项目， 研究开发一个操作性条件反射研究范式，包括 Maier 3-table问题的一些独特之处 科目 将接收视觉或听觉提示，并被要求识别 适当的提示设置，或者可能是提示序列， 奖励 (5)第五个目标是培养少数民族大学生， 行为精神药理学的研究方法 心理健康研究领域的研究生培训

There are five specific long-term aims for this research plan: (1) The first aim is to establish a new animal model for studying the effects of drugs on cognitive functioning. Maier's 3-table reasoning apparatus will be introduced as a unique tool for testing the ability of rats to integrate information learned in one chemical state with information learned in another chemical state to solve a spatial location problem for a food reward. Research has shown that the processes involved in solving this problem are different from those involved in most learning tasks which depend upon the association of contiguous events (Maier, 1932a; Stahl & Ellen, 1974). The second aim is to establish the classes of drugs for which this phenomenon occurs. Both non-prescription drugs and controlled substances will be studied. It is hypothesized that state- dependent performance occurs for drugs such as caffeine and nicotine as well as for abused controlled substances such as morphine and methadone. (3) A third aim is to determine if state-dependent performance under one drug (such as morphine) can be blocked by another drug (such as naloxone) or whether the drug and blocker combination from what is essentially a third chemical state. (4) A fourth aim is to initiate several pilot studies to develop an operant conditioning research paradigm that includes some of the features that make the Maier 3-table problem unique. Subjects will receive a visual or an auditory cue and be required to identify the appropriate cue set, or perhaps a cue sequence, necessary for a food reward. (5) A fifth aim is to train minority undergraduate students in the research methods used in behavioral psychopharmacology to prepare them for graduate training in a mental health research field.