ELECTROCHEMICAL TREATMENT OF TUMORS WITH DC CURRENT

描述（改编自申请人的摘要）：电化学 癌症的ECT治疗包括将铂阳极插入到 肿瘤中心和铂阴极进入肿瘤周围。 在阳极和阴极之间维持直流电30 每立方100库隆布的剂量， 厘米。中国的辛玉玲博士总结了2516年的结果 第一届国际研讨会上66家医院的病例 癌性肿瘤的电化学治疗1992年10月20日至30日在北京。 主要病例是肺癌、肝癌、皮肤癌和乳腺癌。 在 此外，还治疗了18种其他类型的肿瘤。 特别适用于年老体衰，身体虚弱， 手术、放疗或化疗。ECT方法被证明是非常 对浅表肿瘤有效，与 传统的手术、放疗或化疗治疗深部肿瘤。 替代方法简单、经济。 为了让这个 在美国，基础研究必须 在临床试验之前进行。与 中国科学家，试点研究旨在获得初步的 动物中定量剂量反应关系的结果。 肿瘤反应的机制将通过测量 细胞环境。 在未来的大规模研究中， 学科研究将结合专业知识进行， 电子工程，生理学，生物化学，细胞生物学， 免疫学、病理学、化学疗法和放射疗法。 工程 研究将调查肿瘤组织电导率、电流分布 电极配置，使治疗方法标准化 这样就可以比较不同医院的结果。生物 研究将量化各种肿瘤中的剂量反应关系， 尺寸.将研究生理和组织学影响。免疫 我们会详细研究对电休克疗法的反应。 ECT与 放疗和化疗都将被探索。 实验室结果将 用于设计临床方案。目标是使电化学 治疗是对抗癌症的有效方法。

DESCRIPTION (Adapted from Applicant's Abstract): Electrochemical treatment (ECT) of cancer involves inserting platinum anodes into the center of a tumor and platinum cathodes into the tumor periphery.A direct current is maintained between the anodes and cathodes for 30 minutes to several hours, for a dose of 100 coulombs per cubic centimeter. Dr. Xin Yu-ling of China summarized the results of 2516 cases from 66 hospitals at the 1st International Symposium on Electrochemotherapy of Cancer Tumors in Beijing October 20-30, 1992. The primary cases were cancer of the lungs, liver, skin and breast. In addition, 18 other types of tumors were treated.This method is especially suitable for elderly or weak patients who are unable to endure surgery, radiation or chemotherapy.The ECT method was shown to be very effective for superficial tumors and was comparable to or better than conventional surgery, radiation or chemotherapy for deep tumors.This alternative method is simple and economical. In order to make this method available for patients in the United States, basic research must be conducted before it can be clinically tested.In collaboration with the Chinese scientists, pilot studies were designed to obtain preliminary results for quantifying dose response relationships in animals. Mechanisms of tumor response would be studied by measuring changes in a cellular environment. In future large scale studies, inter- disciplinary research would be conducted combining expertise in electrical engineering, physiology, biochemistry, cell biology, immunology, pathology, chemotherapy and radiation. The engineering study would investigate tumor tissue conductivity, current distribution and electrode configuration.The treatment method would be standardized so that results from different hospitals can be compared. Biological studies would quantify dose response relationships in tumors of various sizes. Physiological and histological effects would be studied. Immune response to ECT would be examined in detail. Combinations of ECT with radiation and chemotherapy would be explored. Laboratory results would be used to design clinical protocols. The goal is to make electrochemical treatment a useful method for fighting cancer.