IMMUNOMORPHOLOGIC BASIS FOR SIV PATHOGENECITY

由于获得性免疫缺陷综合征(AIDS)是第一个 六年前报道的，发病率持续上升。 细菌分子生物学研究的重大进展 人类免疫缺陷病毒(HIV)，病原体，有 发生在这段时间内，但病原体 导致不同组织形态改变的机制 器官(如脑、淋巴结、皮肤、胃肠道) 很大程度上是未知的。这一空白的部分原因可以用 涉及的伦理、实用和流行病学方面的考虑 识别和研究血清阳性的人 随后发展成艾滋病。然而，这样的工作可能是 帮助建立了艾滋病的动物模型。 猴免疫缺陷病毒(SIV)是一种嗜T细胞慢病毒 与艾滋病毒有惊人的相似之处，它导致了惊人的 与恒河猴类似的免疫缺陷综合征。这项工作 本提案中概述的旨在1)确定细胞目标 SIV-感染，2)时间序列免疫形态学研究 感染期间淋巴器官的变化，以及3)与 这些发现与特定细胞的体外功能变化有关 表型。通过这项工作获得的结果可以提供 对SIV和HIV发病机制的重要见解- 相关临床疾病。

Since Acquired Immunodeficiency Syndrome (AIDS) was first reported six years ago, the incidence has relentlessly increased. Great advances in the understanding of the molecular biology of human immunodeficiency virus (HIV), the etiologic agent, have occurred during this time period, but the pathogenetic mechanisms leading to the morphologic alterations in various organs (e.g. brain, lymph node, skin, gastrointestinal tract) are largely unknown. Part of this void may be explained by the ethical, practical and epidemiological considerations involved in identifying and studying seropositive individuals who will subsequently develop AIDS. Such work, however, could be facilitated with an animal model for AIDS. Simian immunodeficiency virus (SIV) is a T-cell tropic lentivirus with remarkable parallels to HIV, and it induces a strikingly similar immunodeficiency syndrome in rhesus monkeys. The work outlined in this proposal seeks to 1) identify cellular targets of SIV-infection, 2) study the chronological immunomorphologic changes in lymphoid organs during infection, and 3) correlate these findings with in vitro functional alterations of specific cell phenotypes. The results obtained by this work may provide important insights into the pathogenesis of both SIV- and HIV- related clinical disease.