Circadian rhythm disruption and metabolic function

轮班工作是肥胖和糖尿病的一个研究不足的风险因素。由于轮班工作扰乱了荷尔蒙和睡眠节律，饮食模式和光照，异常的节律可能是代谢疾病的一个致病因素。这种联系缺乏直接证据，其潜在机制也不清楚。该项目旨在了解轮班工作如何导致糖尿病和肥胖，这是设计和测试潜在干预措施所必需的知识。

Shiftwork is an under-researched risk factor for obesity and diabetes. Because shiftwork disrupts hormonal and sleep rhythmicity, eating patterns and light exposure, abnormal rhythmicity may be a causal factor in metabolic disease. Direct evidence for the link is lacking and the underlying mechanisms responsible are unknown. This project aims to understand how shiftwork may lead to diabetes and obesity, knowledge essential for the design and testing of potential interventions.