Circulating tumor DNA to monitor treatment response and resistance in mantle cell lymphoma

许多癌症会将少量的DNA脱落到患者的血液中。基因组技术的最新进展现在允许在外周血中准确测量小水平的癌症DNA。DNA水平的变化有可能用作疾病进展和/或对癌症治疗反应的特异性标志物。该项目将评估是否可以通过简单的血液检测来测量这种DNA，以连续跟踪接受套细胞淋巴瘤治疗的患者。

Many cancers shed small amounts of DNA into the patient’s bloodstream. Recent advances in genomic technologies now allow small levels of cancer DNA to be accurately measured in the peripheral blood. Changes in DNA levels have the potential to be used as specific markers of disease progression and/or response to cancer therapy. This project will evaluate if this DNA can be measured from a simple blood test to serially follow patients receiving treatment for mantle cell lymphoma.