Clarifying the pathogenic role of arousal-hyperventilation in obstructive and central sleep apnoea: Testing fundamental pathophysiological mechanisms and a strategic new treatment

该项目旨在了解阻塞性睡眠呼吸暂停(OSA)患者在深度睡眠时呼吸更稳定的机制。一项新开发的分析技术将用于检查OSA患者睡眠期间呼吸努力的变化，以及与呼吸诱导唤醒的相互作用。此外，将测试和改进一种旨在稳定呼吸的新疗法，以期为阻塞性睡眠呼吸暂停症和中枢性睡眠呼吸暂停症提供新的治疗选择。

This project is designed to understand the mechanisms underpinning much more stable breathing during deep sleep in obstructive sleep apnoea (OSA). A newly developed analytical technique will be used to examine breathing effort changes across sleep, and interactions with respiratory-induced awakenings in OSA patients. In addition, a new treatment designed to stabilise breathing will be tested and refined towards a new treatment option for OSA and for central sleep apnoea.