A New Iron Age: Atom efficient P-C bond forming reactions with simple, designed iron catalysts

催化是使化学反应在较低温度下进行得更快的过程。绝大多数化学工业依赖于开发催化，因此使对制药、农用化学品和精细化学工业至关重要的工业过程变得更容易、更具成本效益。催化作用使我们能够通过形成和断裂特定的化学键来精确地修改化学结构。因此，催化剂设计是一项极其重要和至关重要的工作：这是释放新的反应性和新的键形成方法的关键。这个项目研究的是催化剂的设计，这些催化剂包含令人震惊的简单主题以及丰富和廉价的铁中心。铁也是生物相容和无毒的，为我们的目标反应：氢磷化提供了坚实的基础。这些反应允许在高效的反应条件下合成碳-磷键，很容易形成关键的基序或新的结构。不能低估含磷基序的制备，从而能够制备对许多关键制造部门至关重要的新配体、有机催化剂和生物相关基序。除此之外，我们将开发这种碳-磷键形成化学，用于制备新的构建块，以构建不燃烧塑料(用于先进电子设备的高价值材料和阻燃工业中的商品化学品)。目的：*研究它们在100%原子经济过程中的潜力，这些过程使分子与制药和农用化学工业相关。*通过开发一条通往含磷塑料的积木的新路线来生产高价值化学品；这一新路线使人们能够获得新塑料。

Catalysis is the process by which chemical reactions are made to run faster at lower temperature. The vast majority of chemical industries rely on developing catalysis therefore making vital industrial processes, fundamental to the pharmaceutical, agrochemical and fine chemical industries, easier and more cost efficient. Catalysis allows us to precisely modify chemical structure through the ability to make and break specific chemical bonds. Catalyst design is therefore an incredibly important and vital undertaking: the key to unlocking new reactivity and new bond forming methods.This project looks into the design of catalysts which contain staggeringly simple motifs along with abundant and inexpensive iron centre. Iron is also biocompatible and non-toxic providing a strong foundation for our targeted reaction: hydrophosphination. These reactions allow the synthesis of carbon-phosphorus bonds using efficient reaction conditions, forming key motifs or new architectures with ease. The preparation of phosphorus-containing motifs cannot be underestimated, allowing the preparation of new ligands, organocatalysts and biologically relevant motifs vital to a host of crucial manufacturing sectors. Beyond this we will develop this carbon-phosphorus bond forming chemistry for the preparation of new building blocks to construct non-burning plastics (high value materials used in advanced electronic devices and as commodity chemicals in the flame retardants industries).The aim: * Investigate their potential in 100% atom-economic processes which make molecules relevant to the pharmaceutical and agrochemical industries. * Generate high value chemicals by developing a new route to the building blocks for phosphorus-containing plastics; this new route gives access to new plastics.