INFANTS OF HTLV-III/LAV SEROPOSITIVE MOTHERS

在最近居住在迈阿密的海地移民中，血清的流行率 HTLV-III/LAV抗体为2-9%。海地出生的妇女在 迈阿密杰克逊纪念医院每年有2200名和2500名婴儿； 其中大约20名婴儿将发展为临床证据 每年HTLV-III/LAV感染。这些快递至少占90% 在戴德县海地移民出生的所有婴儿中。我们建议 确定生下孩子的血清阳性母亲的比例 出现临床症状的血清阳性、病毒阳性婴儿 与HTLV-III/LAV感染有关。血清阳性和血清阴性 血清阳性母亲的婴儿将被跟踪相同数量的婴儿。 对血清阴性母亲的婴儿进行为期两年的评估 他们的结果。从这项基于人口的研究中获得的信息将 在两个主要领域具有重要意义。首先，来自 母亲将被用来评估患有疟疾的妇女对未出生婴儿的风险 HTLV-III/LAV感染。第二，以人口为基础的 这项研究将提供更完整的临床谱信息。 这一人群中婴儿感染HTLV-III/LAV。

Among recent Haitian emigrants living in Miami the prevalence of serum antibodies to HTLV-III/LAV is 2-9%. Haitian-born women deliver between 2200 and 2500 infants annually at Jackson Memorial Hospital in Miami; approximately 20 of these infants will develop clinical evidence of HTLV-III/LAV infection each year. These deliveries constitute at least 90% of all births among Haitian emigrants in Dade County. We propose to determine the proportion of seropositive mothers that give birth to seropositive, virus-positive infants that develop clinical syndromes associated with HTLV-III/LAV infection. Seropositive and seronegative infants of seropositive mothers will be followed with a comparable number of seronegative infants of seronegative mothers for two years to assess their outcome. Information obtained from this population-based study will be of significance in two major areas. First, the information from the mothers will be used to assess the risks to unborn infants of women with HTLV-III/LAV infection. Second, the population-based character of the study will provide more complete information on the clinical spectrum of HTLV-III/LAV infection among infants in this population.