REGULATION OF THE LOWER ESOPHAGEAL SPHINCTER

在一项关于调节下呼吸道运作的因素的持续研究中， 食管括约肌，研究将在食管顺利进行 负鼠和猫的肌肉。 分离的肌肉条，1 cm x 1 mm x 1 mm 将通过电子显微镜进行研究，以寻找 神经和肌肉形态，将与建立 括约肌肌肉和括约肌肌肉之间的生理差异 食管体 类似的形态学相关性， 将通过一种特殊的方法来检查这块肌肉的大体情况。 壁内神经丛的形态。 我们将对这一假设进行检验 括约肌与食管体肌的不同之处在于 关于负责紧张性收缩的钙源， 括约肌和钙调素在钙激活中的位置 括约肌张力的过程。

In a continuing study of factors that regulate the operation of the lower esophageal sphincter, studies will be carried out in esophageal smooth muscle of opossums and cats. Isolated strips of muscle, 1 cm x 1 mm x 1 mm will be studied by electromicroscopy to seek distinguishing features of nerve and muscle morphology that will correlate with established physiological differences between muscle of the sphincter and that of the esophageal body. Similar morphologic correlations with the function of this muscle will be sought by a special method to examine the gross morphology of the intramural plexuses. The hypothesis will be examined that the sphincter muscle differs from the esophageal body muscle in respect to the source of calcium responsible for the tonic contraction of the sphincter and for the place of calmodulin in the calcium activation process for sphincteric tone.