POLYIODINATED TRIGLYCERIDES AS LIVER CONTRAST AGENTS

本项目的目的是评估和比较两种新的多碘 甘油三酯衍生物作为肝脏显影放射学造影剂 通过计算机断层扫描(CT)。这些新的亲脂性造影剂包括 通常使用的放射造影剂IOPANIC或其 共轭去乙基苯甲酸酯化为1位和3位 甘油分子。我们实验室的初步工作证明 这些甘油三酯有相当大的潜力作为 肝脏特异性CT造影剂。这些药剂的配方如下 类似于静脉高营养乳化的脂肪乳剂 Intralipid和Liposyn。包括在具体目标的范围内 有以下目标：1)合成足够量的 新的碘酸甘油三酯；2)优化结合技术 将这些制剂制成乳剂，类似于人类用于 (3)肝脏显影的研究。 这些药物在正常和荷瘤兔体内的性质。这个 这些研究的结果将决定是否有理由进一步 在第二阶段的后续研究中对这些药物进行调查。

The aim of this project is to evaluate and compare two new polyiodinated triglyceride derivatives as radiologic contrast agents for hepatic imaging by computed tomography (CT). These new lipophilic contrast agents consist of either the commonly used radiologic contrast agent iopanoic acid or its conjener desethyliopanoic acid esterified to the 1 and 3-position of the glycerol molecule. Preliminary work in our laboratories has demonstrated that these triglyceride iopanoates have considerable potential as hepatic-specific CT contrast agents. These agents will be formulated as lipid emulsions similar to the paventeral hyperalimentation emulsious Intralipid and Liposyn. Encompassed within the scope of the specific aims are the following objectives: 1) to synthesize adequate quantities of the new triglyceride iopanoates; 2) to optimize techniques for incorporating these agents into emulsions analogous to those used in humans for paventeval hypervalimentation; and 3) to study the hepatic opacification properties of these agents in normal and tumor-bearing rabbits. The results from these studies will determine the justification of further investigation of these agents in a Phase II follow-up study.