MUSSEL-ADHESIVE PROTEIN: A NEW TISSUE-ADHESIVE

相当大的努力一直集中在氰基丙烯酸酯的使用上 眼科修复术作为外科手术的辅助或替代的临床眼科修复术 然而，通过反复研究，这些粘合剂被证明是 通过引起炎症、新生血管和 组织坏死。作为氰基丙烯酸酯的替代品，该项目 建议使用贻贝粘附蛋白(MAP)作为组织粘合剂 眼部修复手术。实验将在视网膜和MAP上进行 在体外和原位的角膜组织，并评估强度和 组织粘合的持续时间。MAP是一种粘性很强的粘合剂，与 氰基丙烯酸酯，似乎是生物相容的，可能会增加一个 治疗眼部损伤的有吸引力的替代方案。

Considerable effort has been focused on the use of cyanoacrylates for clinical ocular repair as adjuncts to or in lieu of surgical procedures. Through repeated studies, however, these adhesives have proved to be damaging to the eye tissue by causing inflammation, neovascularization and tissue necrosia. As an alternative to cyanoacrylates, this project proposes the use of mussel-adhesive protein (MAP) as a tissue adhesive in ocular repair. Experiments will be conducted with MAP on retinal and corneal tissue in vitro and in situ, and evaluated for strength and duration of tissue bonding. MAP is a strong adhesive cement and, unlike cyanoacrylates, appears to be biocompatible, and will likely add an attractive alternative for the treatment of ocular injuries.