FACTORS AFFECTING DISTRIBUTION OF MYOCARDIAL FLOW

拟议的研究将继续阐明以下多个因素 控制心肌灌注。和过去一样，这项工作的目的是 回答定义生理学和病理生理学的重要问题 在与人类非常相似的动物模型中冠状动脉血流的变化 生理状态。因此，这项工作将在清醒的动物身上进行 模特们。该研究提案包含两个具体目标：1)逐个节拍 冠脉血流的调节，以及2)物理、药理和 影响心房血流量的神经因素。

The proposed research will continue to elucidate the multiple factors which control myocardial perfusion. As in the past, the aim of this work is to answer questions important in defining the physiology and pathophysiology of coronary blood flow in animal models which are closely akin to man in a physiologic state. Thus, this work will be carried out in awake animal models. The research proposal contains two specific aims: 1) beat-to-beat regulation of coronary blood flow, and 2) physical, pharmacologic and neural factors which affect atrial blood flow.