Clinical and psychosocial changes over late childhood and adolescence and early life determinants of long term clinical outcomes in cystic fibrosis

囊性纤维化是白种人中最常见的缩短寿命的遗传性疾病。肺损伤开始于婴儿期，肺功能福尔斯下降最快的是在青春期，虽然为什么和如何发生这种情况和早期生活的决定因素尚不清楚。这项研究利用了以前的一项研究，该研究监测了3个月至5岁的幼儿，并密切跟踪他们到青春期早期，以调查肺功能下降的保护和风险因素。

Cystic fibrosis is the most common life shortening inherited disease in Caucasians. Lung damage starts in infancy and lung function falls most rapidly in adolescence although why and how this happens and early life determinants are not known. This study takes advantage of a previous study that monitored young children from 3 months to 5 years of life and follows them closely through early adolescence to investigate the protective and risk factors for falling lung function.