REGULATION OF THE LOWER ESOPHAGEAL SPHINCTER

在对调节下游运行的因素的持续研究中 食道括约肌，研究将在食道顺畅进行 负鼠和猫的肌肉。孤立的肌肉条，1厘米x 1毫米x 1毫米 将通过电子显微镜进行研究，以寻找其显著特征 神经和肌肉形态将与已建立的 括约肌与直肠括约肌的生理学差异 食管体。相似的形态与功能的相关性 这块肌肉将通过一种特殊的方法来检查大体 壁内神经丛的形态。我们将检验这一假说。 括约肌与食管体肌肉的区别在于 关于引起紧张性收缩的钙的来源 括约肌及其钙调素在钙激活中的作用 括约肌声调的加工。

In a continuing study of factors that regulate the operation of the lower esophageal sphincter, studies will be carried out in esophageal smooth muscle of opossums and cats. Isolated strips of muscle, 1 cm x 1 mm x 1 mm will be studied by electromicroscopy to seek distinguishing features of nerve and muscle morphology that will correlate with established physiological differences between muscle of the sphincter and that of the esophageal body. Similar morphologic correlations with the function of this muscle will be sought by a special method to examine the gross morphology of the intramural plexuses. The hypothesis will be examined that the sphincter muscle differs from the esophageal body muscle in respect to the source of calcium responsible for the tonic contraction of the sphincter and for the place of calmodulin in the calcium activation process for sphincteric tone.