TRACE BORON QUANTITATION IN PITUITARY TISSUES FOR BNCT

描述：(改编自调查人员的摘要。)脑垂体瘤 约占所有脑瘤的10%。临床表现 这些肿瘤种类繁多，发病率和死亡率都很高， 治疗方式不足。负荷垂体促肾上腺皮质激素和 含10B的生长激素与促肾上腺皮质激素的释放 荷尔蒙或生长激素释放荷尔蒙，将允许杀死 当用热中子照射靶细胞时，导致更多 硼中子俘获疗法(BNCT)有效治疗癌症 技术。能够进行精确测量的技术的可用性 以微升或亚微升为单位的十亿分之一的硼浓度 样品将成为发展硼的重要成分。 特定细胞的递送机制。一种新兴的分析技术， 共振电离光谱(RIS)已显示出极高的 元素分析中的选择性和灵敏度。RIS利用激光 调谐到所需元件独有的状态，从而实现 分析物的有效电离，基本上没有背景。这些 特性可扩展到硼，并将提供一种解决方案 上述目标。仪器和化学的发展是 建议将该方法专门应用于生物中的硼 矩阵。样品雾化选项将与以下内容一起研究 量化选项，包括同位素稀释，以最大限度地减少复杂性 并确保可靠性。

DESCRIPTION: (Adapted from the investigator's abstract.) Pituitary tumors comprise about ten percent of all brain tumors. The clinical presentation of these tumors is diverse, the morbidity and mortality is high, and the treatment modalities are inadequate. Loading pituitary corticotrophs and somatotrophs with 10Boron linked to either corticotrophin releasing hormone or growth hormone releasing hormone, will allow killing of targeted cells when irradiated with thermal neutrons, leading to more effective cancer therapy with the Boron Neutron Capture Therapy (BNCT) technique.The availability of a technique enabling accurate measurements of parts per billion boron concentration in micro, or sub-microliter samples will be an important ingredient in the development of boron delivery mechanisms to specific cells. An emerging analytical technique, Resonance Ionization Spectroscopy (RIS), has demonstrated extremely high selectivity and sensitivity in elemental analysis. RIS utilizes lasers tuned to states unique to the desired element, thereby, achieving efficient ionization of the analyte with essentially no background. These characteristics are extendable to boron, and would provide a solution to the aims described above. Instrumental and chemical developments are proposed to apply this method specifically to boron in biological matrices. Sample atomization options will be investigated together with quantitation options, including isotope dilution, to minimize complexity and assure reliability.