DESIGN AND EVALUATION OF A TRACHEAL PROSTHESIS

I期研究表明，复合气管假体 由刚性外层和可生物降解内层组成 可以成功替代犬颈段气管7.5cm， 没有感染、排斥或挤压。 祭品 允许通过生长和迁移实现管腔内上皮形成， 通过颊粘膜游离移植。 II期研究将继续评估一种刚性化合物 气管假体作为4-6 cm颈部的替代物 气管。 第二项研究将评估刚性复合气管 用于扩大羔羊气管和声门下腔的补片 走向成熟 第三项研究将制定和评估一项灵活的 复合气管假体，以取代长达10厘米的胸部 气管。 提高假体上皮化率的方法 管腔使用生长因子的掺入，细胞外基底 内层膜基质，游离手术颊粘膜 移植物，体外术前组织培养移植将是 评估。

The Phase I study demonstrated that a compound tracheal prosthesis consisting of a rigid outer layer and an inner biodegradable layer can successfully replace 7.5 cm of cervical trachea in the dog without infection, rejection, or extrusion. The prothesis permitted intraluminal epithelization by growth and migration and by free operative buccal mucosal grafts. The Phase II study will continue to evaluate a rigid compound tracheal prosthesis as a replacement for 4-6 cm of cervical trachea. A second study will evaluate a rigid compound tracheal patch to widen the tracheal and sub-glottic lumen in lambs raised to maturity. A third study will develop and evaluate a flexible compound tracheal prosthesis to replace up to 10 cm of thoracic trachea. Methods to increase the rate of epithelization of the prosthetic lumen using incorporation of growth factors, extracellular basement membrane matrix on the inner layer, free operative buccal mucosal grafts, and in-vitro preoperative tissue culture grafting will be evaluated.