NATURAL PRODUCT DRUGS FROM MARINE SOFT-BODIED FAUNA

这个项目的目标是系统地探索海洋， 东北太平洋软体底栖动物 抗肿瘤等生物活性。下列无脊椎动物 将收集到的类群有：多毛类、新月虫、水母类和 肠胃病患者。第一阶段将集中于收集10%的计划 总种数200-250种及创新采集方法评价 包括对沉积物的真空提取和选择性有机浓缩 以促进补充和增加目标的丰度 物种。样本将被提取，并与五人小组进行筛选 人类肿瘤细胞系。活性萃取物将进一步分级 根据生物活性，并用化学方法进行描述。第二阶段 将继续这项工作，NCI将有机会 筛选收藏集。预计新的化学实体，包括 重要的制药活动，将被描述和申请专利；他们 将被授权给政府或制药公司用于 发展。 底栖海洋底栖动物的评估为 药物发现。只有几个区系物种被评估，因为 收集和回忆底栖动物的技术难度 以千克为单位。

The goal of this project is to systematically explore the marine, soft-bodied, benthic infauna of the northeastern Pacific Ocean for antitumor and other biological activities. The following invertebrate groups will be collected: polychaetes, nemerteans, sipunculans and enteropneusts. Phase I will concentrate on collecting 10% of a program total of 200-250 species and on evaluating innovative collecting methods including vacuum extraction of sediments and selective organic enrichment of the sediment to promote recruitment and increased abundance of target species. Samples will be extracted and screened against a panel of five human tumor cell lines. Active extracts will be further fractionated according to biological activity, and described chemically. Phase II will continue this work and the NCI will be given the opportunity to screen the collection. It is expected that new chemical entities, with important pharmaceutical activities, will be described and patented; they will be licensed to the government or pharmaceutical companies for development. The evaluation of benthic marine infauna presents a new opportunity for drug discovery. Only a few infaunal species have been evaluated due to the perceived technical difficulty of collecting and recollecting infauna in kilogram quantities.