SYNTHESES OF 13C LABELED POLYUNSATURATED FATTY ACIDS

许多多不饱和脂肪酸(PUFA)对 人体或潜能的正常发展 动脉粥样硬化、类风湿疾病的预防/治疗药物 关节炎、癌症、I型糖尿病、早产和低血压 出生体重与中枢神经系统发育异常及视力的关系 新生儿。~(13)C标记的多不饱和脂肪酸对代谢和体内~(13)C有意义 核磁共振研究和临床CO(2)-13呼气测试脂肪吸收不良。 第一阶段建议合成一些关键的标记中间体，包括 炔丙基-1，3-13(C)2和炔丙基-2-13C醇 交替碳标记多不饱和脂肪酸13C的合成。第二阶段可能 完成标记中间体的合成和组装 按照公知的方法生产标记的多不饱和脂肪酸。

A number of polyunsaturated fatty acids (PUFA) are either essential for a normal development of the human body or potential prophylactic/therapeutic agents for atherosclerosis, rheumatoid arthritis, carcinogenesis, type I diabetes, premature birth and low birth-weight, and abnormal development of the CNS and visual acuity in newborns. 13C-Labeled PUFA are of interest for metabolic and in vivo 13C NMR studies, and clinical CO(2)-13 breath-test for fat malabsorption. Phase I proposes to synthesize some key labeled intermediates, including propargyl-1,3-13(C)2 and propargyl-2-13C alcohols, that are necessary for the synthesis of PUFA 13C-labeled at alternating carbons. Phase II may complete the syntheses of the labeled intermediates and assemble them following generally known methodologies to produce the labeled PUFA.