GLAUCOMA FILTERING SURGERY: IMPROVED BY DRUG CONJUGATES

描述：（研究者摘要）：滤过手术，当 成功，是降低眼内压的有效方法， 青光眼患者的视野丧失。 手术过滤器的创建 在这些患者中提供了用于房水引流的人工途径， 绕过小梁网 然而，目前这一程序 由于高失败率，仅限于“终末期”青光眼患者 与这个过程有关。 这一程序的失败是由于 过滤器中的疤痕，其随后减少了房水流出， 升高眼压。 最近的临床研究表明，结膜下 注射抗增殖剂。 使用这种类型的 蛋白质结合物递送系统应限制抗增殖剂的使用。 将药剂输送到手术部位以及增加其停留时间。 因此，我们认为， 这种蛋白质结合物递送系统不仅可以提高 过滤手术的速度，而且还减少了副作用和数量 目前与抗增殖治疗相关的注射。

DESCRIPTION: (Investigator's abstract): Filtering surgery, when successful, is an effective method to reduce intraocular pressure and visual field loss in glaucoma patients. The creation of a surgical filter in these patients provides an artificial route for aqueous drainage that bypass the trabecular meshwork. However, this procedure is currently limited to "end stage" glaucoma patients only, due to the high failure rate associated with this procedure. The failure of this procedure results from the scarring in the filter which then reduces aqueous humor outflow and raises IOP. Recent clinical studies have demonstrated that subconjunctival injection of antiproliferative agent. The use of this type of protein-conjugate delivery system should restrict the antiproliferative agent to the surgical site as well as increase its residence time. Hence, this protein-conjugate delivery system should not only improve the success rate of filtering surgeries but also reduce the side effects and the number of injections currently associated with antiproliferative therapies.