NON-SURFACTANT FORMULATION FOR INDUCING AGENTS

不良的，组胺类反应已报告后 给药，如阿法司酮，溶解于 非离子、水性表面活性剂。这些副作用可能会减少或 通过将主要诱导剂阿法松酮与 环糊精已被证明可以改善其他物质的溶解性 类固醇。第一阶段的研究表明这是有希望的 组合。这种配方的成功开发将提供一种 目前上市的剂型的安全替代品，伪装成 诱导剂的非表面活性剂配方。这一准备工作应该 导致过敏副作用的减少，从而使安全和 可靠的麻醉。

Adverse, histaminoid-type reactions have been reported after the administration of anesthetics, such as alfaxalone, solubilized in non-ionic, aqueous surfactants. These side effects may be reduced or eliminated by combining the primary inducing agent, alfaxalone, with cyclodextrins which have been demonstrated to improve solubility for other steroids. Studies resulting from Phase I show promise for this combination. Successful development of this formulation will provide a safe alternative for the currently marketed dosage form in the guise of a non-surfactant formulation for the inducing agent. This preparation should result in a reduction in allergic side effects, thereby allowing safe and reliable anesthesia.