POW! SOFTWARE FOR BIOMEDICAL STUDY DESIGN

此第二阶段SBIR提案涉及PC软件POW！的开发 计算样本大小、统计功率和置信度区间宽度 用于生物医学研究的设计。基于我们的第一阶段设计 说明书，Pow！将有一个方便的用户界面，强调 图形化显示和轻松创建数字表格，并 适用于多种型号和设计。我们的节目将 在Microsoft Windows 3.1下运行，以便自定义表格和 图形输出可以通过以下方式导出到字处理程序或电子表格 Windows DDE。Pow！的值得注意的特点！将包括广泛的 事件间隔时间和重复措施设计方法的覆盖面 研究、评估设计对参数变化的敏感度(例如 更少的患者或比预期更小的影响)，以及上下文- 敏感的帮助设施。图形显示可以是两个或三个- 尺寸(例如，传统的幂曲线、等高线或隐藏线 功率与效应大小和样本量的净曲线图)。战利品！将要 通过向MLAB生成命令文件进行操作，综合软件WE 为数值、图形和符号计算而创建。此链接 将允许POW轻松扩展！作为新的设计或设计计算 出现。

This Phase II SBIR proposal concerns the development of Pow!, PC software to compute sample size, statistical power, and confidence interval width for the design of biomedical studies. Based on our Phase I design specifications, Pow! will have a convenient user interface, emphasize graphical display and easy creation of numerical tables, and be applicable to a wide range of models and designs. Our program will operate under Microsoft Windows 3.1 so that customized tabular and graphical output can be exported to word processors or spreadsheets by the Windows DDE. Noteworthy features of Pow! will include extensive coverage of design methods for time-to-event and repeated measures studies, assessment of design sensitivity to shifts in parameters, (e.g. fewer patients or smaller effects than anticipated), and context- sensitive help facilities. Graphical displays can be two- or three- dimensional (e.g. traditional power curves, and contour or hidden line net plots of power versus effect size and sample size). Pow! will operate by generating command files to MLAB, comprehensive software we created for numerical, graphical, and symbolic calculation. This link will permit easy expansion of Pow! as new designs or design calculations appear.