COMBO: PROGRAM FOR ANALYZING DRUG COMBINATION ASSAYS

COMBO：药物组合测定分析程序

• 批准号: 3492622
• 负责人: BARRY J BUNOW
• 金额: $ 5万
• 依托单位: CIVILIZED SOFTWARE, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1991-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3492622
• 关键词: AIDS therapy; combination chemotherapy; computer assisted medical decision making; computer program /software; computer system design /evaluation; drug adverse effect; drug interactions; evaluation /testing; mathematical model; model design /development; neoplasm /cancer therapy

DESCRIPTION: (Adapted from applicants abstract) COMBO, an interactive computer program for the analysis of drug combination assays is to be developed. Drug combinations play an important role in cancer therapy and anti-microbial therapy, and are increasingly recognized as important in AIDS therapy, and other anti-viral therapy. Assay of drug combinations is a major tool for the identification of new combinations, improving existing combinations, and determination of therapeutic index. Drug combination assays are currently performed at hundreds of sites in medical research institutions and pharmaceutical-biotechnology companies, where COMBO will be equally applicable to efficacy, toxicity, and therapeutic index analysis. COMBO will combine biochemically-motivated model selection of analysis options, effective graphical and tabular presentation of relevant results. COMBO will be programmed in the flexible MLAB environment, permitting the user either to remain within the context of the program or to generalize the data analysis in his own manner, through the provision of the MLAB programming language. The program will contain modules for calibration, data entry and editing, model selection, parameter estimation, graphical and tabular display of residuals, computation of pharmacologically-relevant parameters from the assay. The applicant will develop models for drug interaction which are motivated by practical experience, and analyze them by modern statistical methodologies.

描述：（改编自申请人摘要）COMBO，一个互动的 用于分析药物组合测定的计算机程序将被 开发 药物组合在癌症治疗中发挥重要作用， 抗微生物治疗，并越来越被认为是重要的， 艾滋病治疗及其他抗病毒治疗。 药物组合的含量测定是 识别新组合的主要工具，改善现有的 组合和治疗指数的测定。 药物组合 目前，在医学研究中， 机构和制药生物技术公司，其中COMBO将 同样适用于疗效、毒性和治疗指数 分析. COMBO将结合联合收割机生物化学动机的模型选择， 分析选项，有效的图形和表格显示相关 结果 COMBO将在灵活的MLAB环境中编程， 允许用户保持在程序的上下文内， 以自己的方式概括数据分析，通过提供 MLAB编程语言 该计划将包含模块， 校准、数据输入和编辑、模型选择、参数估计， 残差的图形和表格显示， 药理学相关参数。 申请人将 开发药物相互作用的模型， 并通过现代统计方法进行分析。