COMPUTER ASSISTED CHOLESTEROL REDUCTION: PHASE II

冠心病(CHD)一直是人类死亡和死亡的主要原因 残疾在美国已经有40多年的历史了。相关的年度总成本 冠心病，包括直接医疗和生产力丧失，是 估计超过6000万美元。现在有证据清楚地表明 血液胆固醇水平升高是冠心病的主要原因，最近 据估计，美国超过一半的成年人口。 胆固醇水平会使他们面临患冠心病的风险。给定 数量惊人的美国人，当务之急是发展 易于传播的有效治疗方法。 这一二期项目的目标是继续努力开发 一个有效的、商业上可行的胆固醇自我管理计划 基于手持计算机的使用而减少的费用。这个 计算机化的胆固醇降低计划(CCRP)结合了 以临床为基础的成功项目的关键特征，如声音 营养、锻炼和行为矫正，并将它们包装在一个 手持式电脑。计算机化的交付格式提供了许多独特的 功能，例如，交互式提示、即时反馈和 简化的自我监控，这可能会比 传统的基于人工的自我管理程序。特别是，它可能会 在下列情况下提供加强长期维护所需的结构 许多其他方法都未获成功。这个产品应该有 在渴望有效自我的消费者中具有广泛的吸引力 改变饮食和锻炼习惯的管理方法。 拟议的项目包括对现有的Beta-II进行修改 版本的计算机，并在 为期12个月的临床结果试验。CCRP将与 标准的基于手动的自我管理程序和等待列表控制 一群人。在完成临床试验后，我们会利用 结果，以及我们顾问的意见，以指导进一步 对程序进行了改进。

Coronary heart disease (CHD) has been the leading cause of death and disability in the U.S. for over 40 years. Total annual costs associated with CHD, including direct medical care and lost productivity, is estimated to be over $60 million. Evidence now clearly points to elevated blood cholesterol levels as a major cause of CHD, and recent estimates suggest that more than half of the adult population in the U.S. have cholesterol levels that put them at risk for CHD. Given the staggering numbers of afflicted Americans, it is imperative to develop effective treatment methods that can be readily disseminated. The goal of this Phase II project is to continue our efforts to develop an effective, commercially viable self-management program for cholesterol reduction that is based on the use of a hand-held computer. The computerized cholesterol reduction program (CCRP) incorporates the critical features of successful clinic-based programs, such as sound nutrition, exercise, and behavior modification, and packages them in a hand-held computer. The computerized delivery format offers many unique features, e.g., interactive prompts, instantaneous feedback, and simplified self-monitoring, that may result in greater effectiveness than traditional manual-based self-management programs. In particular, it may provide the structure necessary to enhance long-term maintenance where many other approaches have been unsuccessful. This product should have broad-based appeal among consumers who desire an effective self- management approach to modifying diet and exercise habits. The proposed project includes making modifications to an existing Beta-II version of the computer and testing the resulting Beta-III version in a clinical outcome trial lasting 12 months. The CCRP will be compared with a standard manual-based self-management program and a waitlist control group. Following completion of the clinical trial, we will utilize the results, along with input from our consultants, to guide further refinements to the program.