COMBO--DRUG ASSAY ANALYSIS SOFTWARE

本研究的目标是开发一个COMBO，一个用于 药物活性研究分析，将在个人电脑上运行。 将纳入COMBO的药物研究包括体外酶分析， 组织培养系统和全动物模型。连续、离散、 二进制，生存结果将得到支持。将提供模型 对于单一药物，包括四参数Logistic模型，泛化 逻辑、温度和辐射效应。将提供模型 对于药物组合包括相加、增强、协同、 对抗性，辐射效应，以及多种药物和许多 其他互动方式。Como将使用MLAB建模语言作为 它的计算组件。 Como的设计是为了方便用户使用。与该计划的互动将 通过两个可选接口提供。最新进展 界面是问题/答案，答案通常是空的 (表示采用缺省值)、小整数、十进制数或 一个简短的文本字符串。用户界面将是面向屏幕的、基于 在Windows(3.1或NT)中运行的专门设计的程序上 环境，提供选项中的鼠标/光标选择。 作为COMBO发展的一部分，有必要重新审视 药物反应模型的基础。已经开发了新的型号，并且 在第二阶段将开发更多的模型，以反映 分子机制与经验之间的相互作用 对真实世界数据的分析。

The goal of this research is to produce COMBO, a software package for analysis of drug activity studies, which will run on personal computers. Drug studies to be included in COMBO include in vitro enzyme assays, tissue culture systems, and whole animal models. Continuous, discrete, binary, and survival outcomes will be supported. Models will be provided for single drugs, including a four-parameter logistic, generalized logistic, temperature, and radiation effects. Models will be provided for drug combinations which include additivity, potentiation, synergy, antagonism, and radiation effects, as well as multiple drugs and many other interaction modes. COMBO will use the MLAB modeling language as its computational component. COMBO is designed to be user-friendly. Interaction with the program will be provided through two alternative interfaces. The development interface is question/answer, with the answers typically being nothing (meaning take the default value), a small integer, a decimal number, or a short text string. The user interface will be screen-oriented, based on a specially-designed program operating in the Windows (3.1 or NT) environment, providing mouse/cursor selection among options. As a part of the development of COMBO it has been necessary to re-examine the basis of drug response models. New models have been developed, and additional models will be developed during Phase II which reflect a productive interaction between molecular mechanism and experience in the analysis of real world data.