FETAL HYPOXIA AND CIRCULATORY STATE MONITOR

该项目解决了实时量化的关键需求 胎儿缺氧，这是所有分娩过程中的一种令人担忧的情况，可能导致 脑损伤或死亡。目前，还没有这种对缺氧的直接监测 存在，但每年有一半的新生儿受到一些间接的监测 缺氧的指标。美国妇产科医师学会 妇科医生建议测量新生儿的动脉酸度 通过持续压低的阿普加评分来确定缺氧是否是一种 直接原因。在第一阶段，TTI开发了一种被覆盖的膜 极谱氧传感器，也结合了热敏电阻来测量 局部血液灌注率，以满足这一临床需求。这个头皮- 接触式传感器使用改编自热技术公司的协议 增强型热扩散探头用于测量氧分压(1毫米汞柱) 灌注量(10%)和温度(0.0035摄氏度)。双层膜 也消除了极谱氧气传感器的压力敏感性。 作为操作员特定的校准变异性。该膜由一个 组织接触硅气体透气膜粘结到生理盐水- 饱和水凝胶可在阴极和阴极之间提供电连续性 阳极板。在第二阶段，传感器性能将针对以下方面进行优化 稳定性和时间响应。在探头上的电流电压比 极谱信号的放大将使用混合 电子封装，以减小总探头尺寸。一种可伸缩的钉书钉 将对附着机构进行设计和测试。之后，第二阶段 将致力于对综合系统的评价工作 以及对其临床相关性的验证。这将通过以下方式完成 正在进行的实验中对怀孕母羊胚胎的测量 和我们的临床合作者一起。

This project addresses the critical need for real time quantification of fetal hypoxia, a condition of concern during all births that can lead to brain damage or death. Currently, no such direct monitor of hypoxia exists, yet each year half of births are monitored with some indirect indicator of hypoxia. The American College of Obstetricians and Gynecologists has recommended that arterial acidity be measured in newborns with persistently depressed Apgar scores to determine if hypoxia is a proximate cause. During Phase I, TTI has developed a membrane covered polarographic oxygen sensor which also incorporates a thermistor to measure the local blood perfusion rate to address this clinical need. This scalp- contacting sensor uses protocols adapted from Thermal Technologies' Enhanced Thermal Diffusion Probe to measure oxygen tension (1 mmHg), perfusion (10%) and temperature (0.0035 degrees C). The Bilayer Membrane eliminates pressure sensitivity of the polarographic oxygen sensor as well as operator-specific calibration variability. This membrane consists of a tissue contacting silicone gas permeable membrane bonded to a saline- saturated hydrogel to provide electrical continuity between the cathode and anode. During Phase II, the sensor performance will be optimized for stability and temporal response. The on probe current to voltage amplification of the polarographic signals will be fabricated using hybrid electronic packaging to reduce overall probe size. A retractable-staple attachment mechanism will be designed and tested. Following this, Phase II work will be devoted to both the evaluation of the integrated system as well as verification of its clinical relevance. This will be done through measurements on the fetuses of pregnant ewes in ongoing experimentation with our clinical collaborators.