BIOMEDICAL APPLICATIONS OF NMR SPECTROSCOPY

该提案要求为升级瓦里安XL-200型核磁共振提供资金 使用固态CP/MAS的VARIAN XL-300型光谱仪 固态生物分子和生物分子研究附件 解决方案状态。张博士将研究主宾互动在 环糊精包合物及其与DNA烷化剂的相互作用 体外培养。伯恩博士的研究将强调吖啶类药物--核酸 酸相互作用与药物的多晶性。贝尔德博士将调查 DNA-多环芳烃加合物的结构。卡萨迪博士 将阐明来自更高层次的新型抗肿瘤药物的结构 植物。劳登博士将使用固态核磁共振波谱来研究 聚合物结合的羧酸和氨基酸的结构。

This proposal requests funding for the upgrade of the Varian XL-200 NMR spectrometer to a Varian XL-300 spectrometer with solid-state CP/MAS attachment for the study of biomolecules both in the solid state and solution state. Dr. Chang will study the host-guest interactions in cyclodextrin inclusion complexes and DNA-alkylating agent interactions in vitro. Dr. Byrn's research will emphasize the acridine drugs - nucleic acid interaction and the polymorphism of drugs. Dr. Baird will investigate the structures of DNA-polycyclic aromatic hydrocarbon adducts. Dr. Cassady will elucidate the structures of novel antineoplastic agents from higher plants. Dr. Loudon will use solid state NMR spectroscopy to study the structure of polymer bound carboxylic acids and amino acids.