MASS SPECTROMETER ACCESSORIES

要求提供资金，以便能够购买更新版， 用于Varian MAT 311 A和Finnigan MAT 90质量的附件 光谱仪，以满足用户的需求， 扩展了FAB和EI/CI分析功能。 主 用户群，约占80%， 仪器时间，由15个NIH支持的主要 调查人员每年获得约300万美元， 代表三个机构的十个不同部门 一 还识别了有权访问 15%-20%的时间使用仪器。 所请求的更新和附件分为 两个仪器，包括，对于311 A，修改为高 质量范围，FAB模式下的高灵敏度操作（磁体， 飞行管和E扇区），更新数据系统，新的FAB 枪，一个新的可加热/可冷却的FAB探头，并增加了一个 第1个FFR中的碰撞单元。 对311 A的更新将 提供最先进的FAB质谱仪数据系统 在6 kV时质量范围为5，000 u，与当前质量范围相比 在3 kV时为1400 u。 对MAT 90的更新将扩展 操作能力，包括MIKES能力， 在第二个FFR中的碰撞室中，并采集备用离子体积。 在 此外，还需要第三种颜色的终端， 两个质谱仪共享，导致增加 利用这两种仪器，和一个功率调节器需要， 确保这两种仪器的清洁电源的可用性。 用户的研究领域广泛，从结构 低分子量天然和合成物的解析 产品的鉴定MH+和肽的测序 和分子量大于 1400u。 获取所需的更新和附件， 因此，预计将产生重大的积极影响， 由NIH和其他联邦、州支持的研究项目， 亚利桑那大学的地方，工业和私人机构。

Funds are requested to allow the purchase of updates and accessories for Varian MAT 311A and Finnigan MAT90 mass spectrometers which are needed to meet user demands for expanded capabilities in FAB and EI/CI analyses. The primary user group, which accounts for approximately 80% of the instrument time, consists of 15 NIH supported principal investigators awarded approximately $3.0 M annually, representing 10 different departments at three institutions. A secondary user group is also identified which have access to the instruments for 15-20% of the time. Updates and accessories being requested are divided between the two instruments and include, for the 311A, modifications for high mass range, high sensitivity operation in the FAB mode (magnet, flight tube and E sector), updates to the data system, a new FAB gun, a new heatable/coolable FAB probe and addition of a collision cell in the 1st FFR. The updates to the 311A would provide a state of the art FAB mass spectrometer-data system with a mass range to 5,000 u at 6kV versus a current mass range of 1400 u at 3kV. Updates to the MAT90 would expand the operating capabilities to include MIKES capability by addition of a collision cell in the 2nd FFR and to acquire spare ion volumns. In addition, a third color terminal is requested which would be shared by both mass spectrometers, resulting in increased utilization of both instruments, and a power conditioner needed to insure availability of clean power for the two instruments. Research areas of the users is broad, ranging from structure elucidation of low molecular weight natural and synthetic products to the identification of MH+ and sequencing of peptides and nucleic acid polymers with molecular weights greater than 1400u. Acqusition of the requested updates and accessories is, therefore, expected to have a significant, positive impact on research projects supported by the NIH, and other federal, state, local, industrial and private agencies at the University of Arizona.