MBRS PROGRAM AT RUST COLLEGE

拉斯特学院MBRS项目的重点是 让学生和教职员工接触生物医学研究。因此， 增加少数民族进入生物医学科学的流动。 因此，我们建议将这些焦点置于 以下四(4)种方式：(1)学术充实计划 由叶博士执导，将为学生和教职员工提供 关于生物医学研究的最新研究课题的信息 通过特邀嘉宾演讲系列，访问毕业生和 专业学校、研究(校外)。(2)研究 学生在校园内的发展和培训 《黑人的肾上腺素能受体与高血压》将成为 由E.阿拉法特博士主持。该研究的目标是 了解肾上腺素能受体参与血管紧张素转换酶 导致高血压的可能机制比较 白人和黑人。人们的兴趣主要集中在诱导怀孕上 高血压。血液样本将通过 田纳西大学医学中心，种族混杂 (50%：约50%)。两(2)名学生将参与此活动 第二年和第三年的课程。(3)研究 大鼠的行为和大鼠的高血压“将由 M.I.Shafi博士在Felix Osuji先生的帮助下。侦探们认为 高血压与高血压的类型之间存在相关性 生活。由于以前的大多数研究都是在 因此，夜间或白天的光线可能会造成压力。 从老鼠的角度来看，因为这些是夜间活动的动物。 因此，PI建议研究大鼠的行为(SHR， WKY，DS和HLZ)在黑暗中使用一种新技术 “红外感应摄像”以及在光线下。他们也 建议研究高血压药物的使用是否会改变生活 高血压大鼠的模型。两(2)名学生将参加 这个项目。(4)叶刘淑仪博士将督导有关 一种多底物嘌呤抑制剂的前药方法 到目前为止最好的抑制剂是 阿昔洛韦二磷酸和相关化合物，所有这些也 通过被动扩散到内部而高度带电渗透 酶所在的细胞的位置。我们建议准备 一系列带有溴乙酰基的嘌呤衍生物。 这些中性化合物有可能扩散到 细胞膜，并在反应中与磷酸盐反应 由核苷磷酸化酶本身催化，产生一种有效的 酶的原位抑制物。将有两(2)名学生参与 在这个研究项目中。

The focal points of the MBRS program at Rust College is to expose students and faculty to biomedical research. Thus increasing the flux of minorities into biomedical sciences. Therefore, we are proposing to get to these focal points in the following four (4) ways: (1) Academic enrichment program directed by Dr. F. Yeh will provide students and faculty with the information on current research topics in biomedical research through invited guest speaker series, visits to graduate and professional schools, research (off campus). (2) The research development and training of students on campus in the area of "Adrenergic receptors and Hypertension in Blacks" will be conducted by Dr. E. Arafat. The goal of the study is to understand the participation of the adrenergic receptors in the possible mechanism leading to hypertension as compared in whites and blacks. Interest is focused on pregnancy induced hypertension. Blood samples will be obtained through the University of Tennessee Medical Center with a racial mixture (50%: 50% approx). Two (2) students will participate in this program during the second and third year. (3) The study of Behavior of Rats and Hypertension in Rats" will be supervised by Dr. M. I. Shafi with the help of Mr. Felix Osuji. The PIs believe that there is a correlation between hypertension and pattern of life. Since majority of previous studies are done either in the light at night or during the day time, therefore, may be stressful from rats view points since these are nocturnal animals. Therefore the PIs proposed to study the behavior of rats (SHR, WKY, DS and HLZ) in the dark by a new technique using "infrared sensing video taping" as well as in the light. They also propose to study if the use of hypertensive drugs change the life pattern of hypertensive rats. Two (2) students will participate in this project. (4) Dr. Frank Yeh will supervise the research on "Prodrug approach for a multisubstrate inhibitor of purine nucleotide phosphorylase." The best inhibitors to date are acyclovir diphosphate and related compounds all of which are too highly charged to penetrate by passive diffusion to the interior of the cell where the enzyme is located. We propose to prepare a series of purine derivatives carrying a bromoacetyl group. These neutral compounds have the potential to diffuse across the cell membrane and to react with phosphate, in a reaction catalyzed by nucleoside phosphorylase itself, generating a potent inhibitor of the enzyme in situ. Two (2) students will participate in this research project.