Rosalind Franklin Institute Correlated Imaging Pump Priming

生命科学部门是英国经济的重要组成部分：它拥有超过220，000名员工，为GDP和英国贸易平衡做出了重大贡献，并且对于为患者开发领先的治疗方法至关重要。它以英国在健康和生命科学领域的世界领先研究基地为基础。许多关键的研究突破反过来又得益于工程和物理科学（EPS）研究的进步，这些研究提供了越来越复杂的仪器和方法，以支持对活生物体（从微生物到植物，动物和人体）和生物过程（包括疾病病理学和药物作用）的研究。这一生态系统的所有部分的研发--从基础知识到应用研究再到产品开发--对于实现长期经济增长和农业、粮食安全、医疗保健和公共卫生的持续进步至关重要。历史上的创新模式往往是线性的，涉及一定程度的偶然性。如果物理科学家、工程师、生命科学家和工业界共同努力，并形成规模，颠覆性技术和科学突破将加速发展。这是罗莎琳德富兰克林研究所（RFI）的领域：在哈维尔科学与创新园区设有一个联络点（Hub），与英国各地领先高等教育机构的正式发言人联系在一起，它将整合来自学术界和工业界的互补专业知识，以创建一个国家卓越中心，用于物理科学和生命科学融合的方法开发。新一代跨cm-pm长度尺度的相关成像技术，包括时间和光谱相关性（相关成像，CI主题），这将使我们对细胞和疾病生物学的理解以及某些疾病的非侵入性诊断和治疗发生变化。它将创造高价值的就业机会，保护和吸引外来投资，并推动长期增长;并为政府的创新做出贡献，工业和区域战略。这笔赠款将支持下一代CI的三个关键组成部分的设计和开发（详见BEIS批准的科学和商业案例）即用于在原子水平上可视化动态事件的像差校正脉冲电子显微镜;双束FIB，其形成用于开发集成硬件和软件的平台以及包括传感器的快速直接电子检测器基于GaAs。

The Life Sciences sector forms a key part of the UK economy: it employs over 220,000 people, contributes significantly to GDP and UK balance of trade, and is crucial for developing leading-edge treatments for patients. It is underpinned by the UK's world-leading research base in the health and life sciences. Many key research breakthroughs are, in turn, enabled by advances in engineering and physical sciences (EPS) research - which provide ever more sophisticated instrumentation and methods to support the study of living organisms (from microbes to plants, animals and the human body) and biological processes (including both disease pathology and drug action). R&D across all parts of this ecosystem - from fundamental understanding to applied research to product development - is crucial for the delivery of long-term economic growth and continued advances in agriculture, food security, healthcare andpublic health. Historic models of innovation have often been linear, involving a degree of serendipity. Disruptive technologies and scientific breakthroughs will be accelerated if physical scientists, engineers, life scientists and industry work together, and at scale. This is the domain of the Rosalind Franklin Institute (RFI): with a focal point (Hub) at Harwell Science and Innovation Campus, linked to formal Spokes in leading HEIs across the UK, it will integrate complementary expertise from academia and industry to create a national centre of excellence for methods development at the convergence of the physical and life sciences.A key component of the RFI is to develop disruptive next-generation correlated imaging technologies across cm-pm length scales and including temporal and spectral correlation (the correlated imaging, CI Theme) that will enable step changes in our understanding of cell and disease biology, and the non-invasive diagnosis and treatment of some conditions. It will create high-value jobs, protect and attract inward investment, and drive long-term growth; and contribute to the delivery of the Government's innovation, industrial and regional strategies.This grant is to support the design and development of three key components for the next generation of CI ( as detailed in the science and business cases approved by BEIS) namely an aberration corrected pulsed electron microscope for visualising dynamic events at the atomic level; a dual beam FIB which forms a platform for the development of integrated hardware and software and a fast direct electron detector including a sensor based on GaAs.