A World-Leading National Network for NMR in the Physical and Life Science: Very-High Field Infrastructure at Sheffield

我们将通过升级谢菲尔德大学的核磁共振设施，为英国核磁共振和更广泛的物理和生命科学研究界提供最先进的超高场核磁共振能力。这将包括一个现有的800 MHz系统，该系统将升级为现代冷冻探针和控制台，并专注于溶液NMR应用，特别是那些需要高压的应用。谢菲尔德核磁共振设施将由现有的工作人员运行，为非核磁共振专家用户提供溶液核磁共振的专业知识，并将成为英国核磁共振仪器的中心和辐射网络的一个组成部分，为整个英国研究界的利益而运行。NMR光谱是所有分析工具中最通用的;它提供了对分子结构，动力学和相互作用的见解。超高场和甚高场NMR提供的更高灵敏度和分辨率具有变革性，可提供在较低场强下无法获得的信息。谢菲尔德核磁共振设施的新能力将支持、扩展和加强北部和整个英国的研究活动（参见学术受益人）;支持和扩大先进化学和生物材料、治疗学、生物技术和可再生能源的研究;并催化新的学术与工业合作，重点关注和利用N8和英国范围内的卓越领域。例如：（1）溶液中生物和化学分子以及超分子聚集体的结构测定;（2）线性多肽折叠成复杂的生物活性3D结构，以及在神经退行性疾病和癌症中这些过程可以改变或颠覆的方式;（3）催化过程，以及复杂材料的结构和动力学的详细分析;（4）完整细胞和有机体内的代谢：联合王国的研究支持加强联合王国在关键优先领域竞争地位的目标。通过提供最先进的仪器和专业知识，拟议的谢菲尔德核磁共振设施将使英国研究界能够继续在与国家议程和战略优先事项相一致的研究挑战范围内做出重大贡献，并对工业战略挑战和全球挑战研究基金等倡议作出快速灵活的反应。我们将兑现对NMR的这一重大投资签署人：（1）根据国家优先事项，如先进材料，可再生能源，工业生物技术和合成生物学，以及核心健康挑战，推进具有挑战性的科学议程;（2）通过利用我们的集体知识和经验，并通过课程和暑期学校为社区提供培训，确保英国处于解决方案状态下核磁共振技术发展的最前沿;（3）吸引工业支持、伙伴关系和参与，建立在利用我们的科学能力和资产支持经济增长的良好集体记录基础上;（4）最大限度地有效利用资本资产，以确保有效提供核磁共振接入，在长期可持续发展计划内，利用我们在设备共享以及运营和管理国家设施方面的开创性经验;（5）与八国集团的核心个人和集体机构战略保持一致;（6）建立年度报告制度和研讨会，以传播研究结果和开辟新的研究战略，并使用确定的关键绩效指标监测绩效。

We will deliver access to state-of-the-art very high field NMR capabilities to the UK NMR and wider research community across the physical and life sciences through the upgrading of the NMR Facility at the University of Sheffield. This will comprise an existing 800 MHz system that will be upgraded with a modern cryoprobe and console and focus on solution NMR applications, especially those requiring elevated pressure. The Sheffield NMR Facility will be run by existing staff to provide expertise in solution NMR to non-NMR specialist users, and will be one component of a UK hub and spoke network of NMR instrumentation to be run for the benefit of the whole UK research community. NMR spectroscopy is the most versatile of all the analytical tools; it provides insights into molecular structure, dynamics, and interactions. The higher sensitivity and resolution delivered with ultra- and very-high field NMR are transformative, providing information not accessible at lower field strength. The new capabilities of the Sheffield NMR Facility will support, extend and enhance research activities, both in the north and in the UK as a whole (see Academic Beneficiaries); enable and expand research in advanced chemical- and bio-materials, therapeutics, biotechnology and renewable energy; and catalyse new academic-industrial collaborations, focusing on and exploiting areas where there is excellence in the N8 and UK-wide. Examples include:(1) Structure determination of biological and chemical molecules and supra-molecular aggregates in solution;(2) Folding of linear polypeptides into complex biologically-active 3D structures, and the ways in which these processes can be altered or subverted in neurodegenerative diseases and cancer;(3) Catalytic processes, and the detailed analysis of the structure and dynamics of complex materials;(4) Metabolism within intact cells and organisms.UK research support targets that strengthen the UK's competitive position in key priority areas. By providing ready access to state-of-the-art instrumentation and expertise, the proposed Sheffield NMR Facility will enable UK research communities to continue to make major contributions across the range of research challenges aligned with national agendas and strategic priorities, and to respond rapidly and flexibly to initiatives such as the Industrial Strategy Challenge and the Global Challenges Research Funds.We will deliver on this major investment in NMR by: (1) Progressing a challenging scientific agenda based on national priorities such as advanced materials, renewable energy, industrial biotechnology and synthetic biology, and core health challenges;(2) Ensuring that the UK is at the forefront of NMR technique development in the solution state, by capitalising on our collective knowledge and experience, and providing training to the community through courses and summer schools; (3) Attracting industrial support, partnerships and engagement, founded upon a strong collective track record of using our scientific capabilities and assets to support economic growth; (4) Maximising the effective use of capital assets to ensure efficient provision of NMR access, building on our pioneering experience in equipment sharing, and operating and managing national facilities, within a long-term sustainability plan; (5) Aligning with the core individual and collective institutional strategies in the N8; (6) Developing annual reporting systems and symposia to disseminate findings and open new research strategies, and monitoring performance using defined Key Performance Indicators.