A comparative cognitive and neuroimaging study of pre-diagnosis and symptomatic individuals with Huntingtons disease

亨廷顿病（HD）是一种以运动、认知和精神障碍为特征的疾病。神经成像技术提供了一系列可以表征潜在大脑变化的测量方法。这项研究将使用一系列临床、行为和脑成像技术，以发现诊断前和早期症状性HD变化的最敏感和最可靠的标志物。只有在确定了标记物后，才能对治疗干预措施进行测试。

Huntington's disease (HD) is characterized by motor, cognitive and psychiatric disturbance. Neuroimaging techniques provide a range of measures that can characterize underlying brain changes. This study will use a range of clinical, behavioural, and brain imaging techniques to uncover the most sensitive and reliable marker of change in both pre diagnostic and early symptomatic HD. Therapeutic interventions can only be tested once markers have been identified.