Comparative and Evolutionary Genomics of Schistosomes –Identifying Genes Associated with Parasitism, and Novel Drug and Vaccine Targets

血吸虫病仍然是全球人类疾病和死亡的重要原因。我的项目提出了比较基因组学和进化分析最近测序的寄生虫类群和所有公开的扁形虫基因组。该研究将为识别寄生虫-宿主相互作用的重要基因功能和途径提供新的见解，揭示新的候选抗寄生虫药物或疫苗靶点，并识别与膀胱肿瘤发生相关的基因。埃及血吸虫

Schistosomiasis remains an important cause of human illness and death globally. My project proposes comparative genomics and evolutionary analysis of recently sequenced schistosome taxa and all publicly available flatworm genomes. The study will provide novel insights into identifying gene functions and pathways important for the parasite-host interaction, reveal novel candidate anti-schistosome drug or vaccine targets, and identify genes associated with bladder tumorogenesis in S. haematobium.