UH-VA ALCOHOLISM TREATMENT MATCHING CRU

该提案将表明，休斯顿退伍军人大学 行政及临床研究组将提供一个极好的网站， 进行一项患者-治疗匹配的多年试验， 响应NIAAA合作协议请求（RFA AA-89- 02 B）。 临床人群由每年约500名患者组成， 进入酒精中毒治疗计划康复单位（病房210） 从e排毒单位，治疗男性，中年退伍军人广泛 酗酒和严重的心理社会适应史 问题所有人都有酗酒的初步诊断。当前 治疗包括一个为期28天的结构化广泛的计划。 为了在本网站以及其他可能的设置中考虑， UH-VA CRU根据阶段提出了两种特定的治疗匹配 以及改变跨理论模型的过程。变化的阶段 代表了变化过程的时间和动机方面 个人从预先考虑到行动， 然后是维护。处于变革早期阶段的个人将 与动机/决策成分相匹配。界后期 行动和维持的阶段将与自我效能相匹配 基于干预。 匹配的，不匹配的不匹配的受试者 假设对常规护理条件的反应不同， 决策/动机增强条件和效能增强 干预条件分层线性模型分析程序 除了更传统的混合假设之外，还将用于测试这些假设 模型ANOVA设计。 现有的患者人群，概念和理论基础 匹配，以研究为导向的治疗设置和一组坚实的 具有治疗匹配经验的研究者使UH-VA CRU 很有资格成为这种合作治疗的积极参与者 匹配项目。

This proposal will demonstrate that a University of Houston-Veterans Administration Clinical Research Unit would provide an excellent site to conduct a multiyear trial of patient-treatment matching capable of responding to the NIAAA cooperative agreement request (RFA AA-89-02B). The clinical population consists of approximately 500 patients r year who enter the alcoholism treatment program rehabilitation unit (Ward 210) from e Detox unit which treats male, middle aged veterans with extensive histories of problematic drinking and serious psychosocial adjustment problems. All have a primary diagnosis of alcoholism. The current treatment consists of a 28 day structured broad based program. For consideration at this site as well as other possible settings, the UH-VA CRU proposes two specific treatment matchings based on the stages and processes of change the transtheoretical model. The stages of change represent a temporal and motivational aspect of the process of change with individuals moving from Precontemplation Contemplation to Action and then to Maintenance. Individuals in the early stages of change will be matched with a motivational/decisional component. Those in the later stages of action and maintenance will be matched with a self-efficacy based intervention. Matched, unmatched mismatched subjects are hypothesized to respond differentially to a regular care condition, a decisional/motivational enhanced condition and an efficacy enhanced intervention condition. Hierarchical Linear Modeling Analytic procedures will be used to t these hypotheses in addition to more traditional mixed model ANOVA designs. The available patient population, the conceptual and theory based matchings, a research oriented treatment setting and a solid group of investigators who have treatment matching experience make the UH-VA CRU well qualified to be an active participant this collaborative treatment matching project.