UH-VA ALCOHOLISM TREATMENT MATCHING CRU

这项提案将证明休斯顿退伍军人大学 行政临床研究单位将提供一个很好的地点来 进行多年的患者-治疗匹配试验，能够 响应NIAAA合作协议请求(RFA AA-89-02B)。 临床人群由每年约500名世界卫生组织患者组成。 进入酒精中毒治疗计划康复单元(210号病房) 来自e排毒单位，该单位为男性、中年退伍军人提供广泛的 有问题饮酒史和严重的心理社会适应史 有问题。所有人都被初步诊断为酗酒。海流 治疗包括28天的有组织的基础广泛的计划。 对于本站点的考虑以及其他可能的设置， UH-VA CRU根据分期提出了两种具体的治疗匹配方案 以及改变跨理论模型的过程。变革的各个阶段 代表变革过程中的一个暂时的和激励的方面 随着个体从预想、沉思到行动 然后是维护。处于变革早期阶段的个人将是 与激励/决策部分相匹配。后者中的那些 行动和维持阶段将与自我效能相匹配 以干预为基础。匹配的、不匹配的、不匹配的对象是 假设对常规护理条件做出不同的反应， 决策/动机增强的条件和效能增强 干预条件。分层线性建模分析程序 除了更传统的混合假设外，还将用于测试这些假设 模型方差分析设计。 可利用的患者群体、概念和理论基础 匹配，以研究为导向的治疗环境和一组坚实的 有治疗配对经验的研究人员制作了UH-VA CRU 非常有资格成为这一合作治疗的积极参与者 匹配项目。

This proposal will demonstrate that a University of Houston-Veterans Administration Clinical Research Unit would provide an excellent site to conduct a multiyear trial of patient-treatment matching capable of responding to the NIAAA cooperative agreement request (RFA AA-89-02B). The clinical population consists of approximately 500 patients r year who enter the alcoholism treatment program rehabilitation unit (Ward 210) from e Detox unit which treats male, middle aged veterans with extensive histories of problematic drinking and serious psychosocial adjustment problems. All have a primary diagnosis of alcoholism. The current treatment consists of a 28 day structured broad based program. For consideration at this site as well as other possible settings, the UH-VA CRU proposes two specific treatment matchings based on the stages and processes of change the transtheoretical model. The stages of change represent a temporal and motivational aspect of the process of change with individuals moving from Precontemplation Contemplation to Action and then to Maintenance. Individuals in the early stages of change will be matched with a motivational/decisional component. Those in the later stages of action and maintenance will be matched with a self-efficacy based intervention. Matched, unmatched mismatched subjects are hypothesized to respond differentially to a regular care condition, a decisional/motivational enhanced condition and an efficacy enhanced intervention condition. Hierarchical Linear Modeling Analytic procedures will be used to t these hypotheses in addition to more traditional mixed model ANOVA designs. The available patient population, the conceptual and theory based matchings, a research oriented treatment setting and a solid group of investigators who have treatment matching experience make the UH-VA CRU well qualified to be an active participant this collaborative treatment matching project.