CONTINUING STUDIES OF CAT ALLERGY

引入了额外的标准化猫提取物，结果是 对这些提取物的重新评估，以及对 萃取物。猫提取物现在可能含有：(A)毛皮、(B)毛皮、毛发和 头皮屑，(C)毛发和头皮屑，(D)浓缩猫砂，或(E)任何混合物 产品中所定义的这些材料。 目前对猫提取物效力的释放试验是径向的。 FEL D 1含量的免疫扩散试验，该试验测量 猫的主要过敏原。由于原始材料的可变性， 蛋白质和非FEL d1变应原水平的差异 在LAP开发的检测中被检测到。正在开发两种新的分析方法 标准猫血清中猫血清相对含量的检测 使用Rast抑制和荧光相关的萃取物 效价(FRP)测试。等电聚焦与斑点放射免疫 电聚焦(Brief)程序也被用来评估 这些猫的萃取物。对这些程序的初步研究表明 它们之间可能存在显著的成分差异 萃取物。对这些数据的审查仍在进行中，以确定 这些发现的意义。

The introduction of additional standardized cat extracts has resulted in a re-evaluation of these extracts, and the allergic response to the extracts. Cat extracts now may contain: (a) pelt, (b) pelt, hair and dander, (c) hair and dander, (d) concentrated cat wash, or (e) any mix of these materials as defined in the product. The current release test for potency of cat extracts is a radial immunodiffusion test for Fel d 1 content that measures one of the primary allergens of cat. Due to variability in source material, differences in protein and non-Fel d 1 allergen levels have been detected in assays developed by LAP. Two new assays are being developed to examine the relative quantity of cat serum in standardized cat extracts using the RAST inhibition and a Fluorescent Relative Potency(FRP) tests. Isoelectric Focusing(IEF) and Blotted RadioImmuno ElectroFocusing (BRIEF) procedures are also being utilized to evaluate these cat extracts. Preliminary work with these procedures suggests that possible significant compositional differences may exist between extracts. Review of these data is still in progress to determine the significance of these findings.